Asialoglycoprotein receptor 1 mediates productive uptake of N -acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

Garth A. Kinberger; Alexey Revenko; Lisa Hettrick; Michael Tanowitz; Thazha P. Prakash; Punit P. Seth

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Asialoglycoprotein receptor 1 mediates productive uptake of N -acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

机译：去唾液酸糖蛋白受体1介导N-乙酰半乳糖胺结合的和未结合的硫代磷酸酯反义寡核苷酸向肝脏肝细胞的有效摄取

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《Nucleic acids research》 |2017年第21期|共页
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Garth A. Kinberger; Alexey Revenko; Lisa Hettrick; Michael Tanowitz; Thazha P. Prakash; Punit P. Seth;
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1. Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes [J] . Tanowitz Michael, Hettrick Lisa, Revenko Alexey, Nucleic Acids Research . 2017,第21期

机译：Asialogloticopotin受体1介导N-乙酰甘酰胺 - 缀合的富含N-乙酰甘酰胺 - 缀合和未缀合的硫代磷酸酯反义寡核苷酸的高效吸收成肝脏肝细胞
2. Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver [J] . Nucleic Acid Therapeutics . 2017,第4期

机译：赋形剂寡核苷酸的共同施用有助于肝脏在肝脏中硫代磷酸酯反义寡核苷酸的生产和非制备吸收的途径
3. Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver [J] . Miller Colton M., Tanowitz Michael, Donner Aaron J., Nucleic Acid Therapeutics . 2018,第3期

机译：受体介导的肝脏磷硫代磷酸酯反义寡核苷酸的摄取
4. Nanoparticulate-mediated delivery of the telomerase inhibiting antisense oligonucleotides for lungcancer therapy: Impact of surface charge on the cellular uptake [C] . N. Nafee, K. Friebel, M. Schneider, Annual meeting exposition of the Controlled Release Society . 2009

机译：纳米颗粒介导的端粒酶抑制性反义寡核苷酸在肺癌治疗中的传递：表面电荷对细胞摄取的影响
5. Pharmacokinetics, pharmacodynamics and metabolism of Bcl-2 antisense phosphorothioate oligonucleotide G3139 (Genasense(R)). [D] . Dai, Guowei. 2005

机译：Bcl-2反义硫代磷酸酯寡核苷酸G3139（Genasense）的药代动力学，药效学和代谢。
6. Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes [O] . Michael Tanowitz, Lisa Hettrick, Alexey Revenko, 2017

机译：去唾液酸糖蛋白受体1介导N-乙酰半乳糖胺结合和未结合的硫代磷酸酯反义寡核苷酸向肝脏肝细胞的有效吸收
7. Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes [O] . Michael Tanowitz, Lisa Hettrick, Alexey Revenko, 2017

机译：Asialogloticopotin受体1介导N-乙酰甘酰胺 - 缀合的富含N-乙酰甘酰胺 - 缀合和未缀合的硫代磷酸酯反义寡核苷酸的高效吸收成肝脏肝细胞

Asialoglycoprotein receptor 1 mediates productive uptake of N -acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

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