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首页> 外文期刊>FEBS Letters >Augmented expression of obese (ob) gene during the process of obesity in genetically obese‐hyperglycemic Wistar fatty (falfa) rats
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Augmented expression of obese (ob) gene during the process of obesity in genetically obese‐hyperglycemic Wistar fatty (falfa) rats

机译:肥胖-高血糖Wistar肥胖(falfa)大鼠在肥胖过程中肥胖(ob)基因的增强表达

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>Expression of the obese (ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the ob gene expression during the development of obesity, we examined the ob gene expression in genetically obese-hyperglycemic Wistar fatty (falfa) rats at several stages of obesity. The ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the ob gene expression.
机译:在许多肥胖啮齿动物模型中,脂肪组织中 obose ob )基因的>表达上调。为了研究肥胖发展过程中 ob 基因表达的调控,我们研究了遗传性肥胖-高血糖Wistar脂肪( falfa 中的 ob 基因表达>)大鼠处于肥胖的几个阶段。 Wistar脂肪大鼠脂肪组织中的 ob mRNA水平明显升高,并在肥胖过程中持续升高。此外,该肥胖模型中的 ob 基因表达在肠系膜脂肪中比在皮下脂肪中更加迅速地增强。而且,肠系膜脂肪中 ob 基因的表达比脂蛋白脂肪酶基因的表达更大。这些结果表明 ob 基因表达的肥胖相关和区域特定调节的存在。

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