首页> 外文期刊>FEBS Letters >The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humans
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The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humans

机译:与EVX基因相邻的HOX复合体,以及其他两个包含同源异形框的基因GBX级和EN级,位于人类的相同2号和7号染色体上

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>Two newly identified human homeobox-containing genes, GBX1 and GBX2, are closely related genes, as are members of the other homeobox genes, EN-1 and EN-2. GBX1 and EN-2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN-1 was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15-p14 and 2q31-q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution.
机译:>两个新发现的人类同源异型框基因 GBX1 GBX2 是密切相关的基因,其他同源异型框基因 EN-1的成员 EN-2 GBX1 EN-2 已映射到染色体7q36。本研究表明, GBX2 被映射到染色体2q37。 EN-1 被定位到2q14号染色体。此外,与 EVX 基因相邻的两个 HOX 复合物 HOXA HOXD 位于染色体7p15-p14和2q31-q37。因此,这些同源异型框基因可能在祖先的基因组上相互链接,并且祖先的染色体片段在进化过程中被复制了。

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