The C‐terminal region as a modulator of rNav1.7 and rNav1.8 expression levels

Acharfi Said; Chahine Mohamed; Vijayaragavan Kausalia

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The C‐terminal region as a modulator of rNav1.7 and rNav1.8 expression levels

机译：C端区域作为rNav1.7和rNav1.8表达水平的调节剂

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>Mammalian cells poorly express rNa_v1.8 channels. In contrast, rNa_v1.7 dorsal root ganglion channels have 90-fold higher peak Na+ current densities. We investigated the role of rNa_v1.7 and rNa_v1.8 carboxy-termini in modulating the expression of rNa_v1.7 and rNa_v1.8 channels in tsA201 cells. Mutations in the ubiquitination site of the C-terminus did not improve rNa_v1.8 current levels. However, rNa_v1.8 chimeras containing the entire or the proximal portion of the rNa_v1.7 C-terminus expressed 3.2-fold and 4.8-fold higher peak current densities, respectively, than parent rNa_v1.8 channels. We conclude that the two Na+ channels may have different endoplasmic reticulum processing signals.

机译：>哺乳动物细胞很难表达rNa _{v 1.8通道。相比之下，rNa _{v 1.7背根神经节通道的Na + 峰值电流密度高90倍。我们研究了rNa _{v 1.7和rNa _{v 1.8羧基末端在调节rNa _{v 1.7和rNa _{v表达中的作用tsa201细胞中的 1.8通道。 C端泛素化位点的突变并没有提高rNa _{v 1.8的当前水平。但是，包含rNa _{v 1.7 C端的全部或近端部分的rNa _{v 1.8嵌合体分别表示峰值电流密度高3.2倍和4.8倍，比父级rNa _{v 1.8通道要多。我们得出结论，两个Na + 通道可能具有不同的内质网加工信号。}}}}}}}}}}

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《FEBS Letters》 |2004年第3期|共页
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Acharfi Said; Chahine Mohamed; Vijayaragavan Kausalia;
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7. The C-terminal region as a modulator of rNav1.7 and rNav1.8 expression levels [O] . Vijayaragavan Kausalia, Acharfi Said, Chahine Mohamed 2004

机译：C端区域作为rNav1.7和rNav1.8表达水平的调节剂

The C‐terminal region as a modulator of rNav1.7 and rNav1.8 expression levels

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