• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation
【24h】

Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation

机译：独特的阳离子囊泡可作为药物输送系统的潜在“纳米出租车”。 体外和体内生物相容性评估

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We evaluate in vitro and in vivo toxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant bis(2-ethylhexyl) sulfosuccinate benzyl-n-hexadecyldimethylammonium (AOT-BHD) in order to investigate their potential application as an oral drug delivery system. Unilamellar vesicles were spontaneously formed by dissolving AOT-BHD in water and their toxicity was evaluated through in vitro and in vivo assays. Cell membrane permeability assays (hemolytic activity, Trypan blue assay) and cellular survival or proliferation (MTT assay) were performed. The results showed that only the highest concentration of vesicles tested (2 mg mL?1) diminished the red blood cells' resistance. In vivo toxicity evaluation was carried out on mice through lethal dose 50 (LD50) experiments. The safety for living organisms in doses lower than 0.05 mg mL?1 and the acid pH stability makes our AOT-BHD vesicles a very promising candidate for oral drug delivery.
机译：我们评估了由阳离子表面活性剂双（2-乙基己基）磺基琥珀酸酯苄基- n <形成的新囊泡在酸性环境中的体外和体内毒性和稳定性。 / em>-十六烷基二甲基铵（AOT-BHD），以研究其作为口服药物递送系统的潜在应用。通过将AOT-BHD溶解在水中自发形成单层囊泡，并通过体外和体内分析评估其毒性。进行细胞膜通透性测定（溶血活性，锥虫蓝测定）和细胞存活或增殖（MTT测定）。结果表明，只有最高浓度的囊泡（2 mg mL ？1 ）才能降低红细胞的抵抗力。通过致死剂量50（LD 50 ）实验对小鼠进行体内毒性评估。剂量低于0.05 mg mL ？1 的生物体的安全性和酸性pH稳定性使我们的AOT-BHD囊泡成为口服药物非常有希望的候选者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号