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首页> 外文期刊>RSC Advances >Preparation, characterization, and protein-resistance of films derived from a series of α-oligo(ethylene glycol)-ω-alkenes on H–Si(111) surfaces
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Preparation, characterization, and protein-resistance of films derived from a series of α-oligo(ethylene glycol)-ω-alkenes on H–Si(111) surfaces

机译：H–Si（111）表面上一系列α-低聚（乙二醇）-ω-烯烃衍生膜的制备，表征和耐蛋白质性

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A series of oligo(ethylene glycol) (OEG)-terminated monolayers were prepared by photo-activated grafting of OEG-alkenes with the general formula CH2CH(CH2)m(OCH2CH2)nOCH3 (abbreviated as Cm+2EGn, m = 8, 9; n = 3–7) on hydrogen-terminated silicon (111) surfaces using different deposition conditions. The films were characterized by contact-angle goniometry, ellipsometry, X-ray photoelectron spectroscopy (XPS) and tested for protein resistance. Films prepared under a higher vacuum showed a higher thickness and exhibited better protein resistance with increasing ethylene glycol (EG) units. Remarkably, the films prepared from C10EGn were generally thicker than those from their corresponding homologues C11EGn, and displayed better resistance to protein adsorption, which were probably due to the odd–even effect from the alkyl chain. Prepared under high vacuum conditions (～10?5 mbar), the C10EG7 films with a thickness of 40 ? adsorbed <0.8% (the detection limit of N 1s XPS) monolayer of fibrinogen in a standard assay. The films remained protein-resistant (adsorbed <3% monolayer of fibrinogen) even after 28 days in phosphate buffered saline (PBS) at 37 °C or 17 days in MC3T3-E1 cell culture with 10% fetal bovine serum at 37 °C. Therefore, the C10EG7 films prepared under high vacuum conditions represent the most protein-resistant and stable films on non-oxidized silicon substrates.
机译：通过光活化接枝通式为CH 2 CH（CH 的OEG烯烃制备一系列低聚乙二醇（OEG）终止的单层> 2 ） m （OCH 2 < / small> CH 2 ） n OCH 3 （缩写为C m +2 EG n ， m = 8、9; n = 3-7）使用不同的沉积条件在氢终止的硅（111）表面上沉积。通过接触角测角法，椭圆偏振法，X射线光电子能谱（XPS）对薄膜进行表征，并测试其蛋白抵抗力。在较高真空下制备的薄膜显示出较高的厚度，并且随着乙二醇（EG）单元的增加，其蛋白抗性也更高。值得注意的是，由C 10 EG n 制备的膜通常比那些厚从它们对应的同源物中C 11 EG n 吸附，可能是由于烷基链的奇偶效应。在高真空条件下（〜10 ？5 mbar）制备，C 10 EG 7 膜，厚度为40？在标准测定中，吸附的血纤蛋白原的单层吸附率<0.8％（N 1s XPS的检测极限）。即使在37°C的磷酸盐缓冲盐水（PBS）中放置28天或在37％10％胎牛血清的MC3T3-E1细胞培养中放置17天后，薄膜仍具有抗蛋白性（吸附的<3％纤维蛋白原单层吸附）。因此，在高真空条件下制备的C 10 EG 7 膜代表了最耐蛋白质和稳定的膜在非氧化硅基板上。

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