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首页> 外文期刊>RSC Advances >Synthesis and investigation of a self-assembled hydrogel based on hydroxyethyl cellulose and its in vitro ibuprofen drug release characteristics
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Synthesis and investigation of a self-assembled hydrogel based on hydroxyethyl cellulose and its in vitro ibuprofen drug release characteristics

机译：基于羟乙基纤维素的自组装水凝胶的合成，研究及其布洛芬的体外释药特性

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Self-assembled cellulose-based hydrogels are a new type of supramolecular architecture with potential in biomedical applications. By our preparation, hydrophobic lauryl side-chains were grafted onto hydroxyethyl cellulose (HEC-C12) and ibuprofen molecules were encapsulated and solubilized by poly(β-cyclodextrin) (β-CDP/IBU). The content of active residual cavities in β-CDP with inclusion abilities in β-CDP/IBU was determined to be 31.3 wt% by the phenolphthalein probe method, then the residual cavities were used to spontaneously form a self-assembled hydrogel (gel-(β)CDP-HEC/IBU) in water with the hydrophobic C12 side-chains on HEC-C12. The critical concentrations of HEC-C12 and β-CDP/IBU in the self-assembled hydrogel were fixed at 30 mg mL?1 and 35 mg mL?1 respectively, as shown by the dynamic viscosity results. The synthesized macromolecules and hydrogels were characterized by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Gel Permeation Chromatography (GPC) and powder X-ray diffractometry (PXRD). A swelling study and the in vitro drug release characteristics of IBU in gel-(β)CDP-HEC/IBU were investigated. The results showed that the loaded content of IBU in gel-(β)CDP-HEC/IBU was 5 wt%, and that IBU encapsulated in gel-(β)CDP-HEC/IBU presented sustained release characteristics over 1440 min. In addition, the Korsmeyer–Peppas kinetic model gave a better correlation for the release of IBU, and the release procedure was a non-Fickian diffusion process.
机译：自组装纤维素水凝胶是一种新型的超分子结构，在生物医学应用中具有潜力。通过我们的制备，将疏水性月桂基侧链接枝到羟乙基纤维素（HEC-C 12 ）上，并将布洛芬分子包封并通过聚（β-环糊精）（β -CDP / IBU）。通过酚酞探针法测定β-CDP中具有包涵能力的β-CDP中活性残留腔的含量为31.3 wt％，然后利用残留腔自发形成自组装水凝胶（gel-（ β）CDP-HEC / IBU）在具有在HEC-C 12 12 侧链的水中>。自组装水凝胶中HEC-C 12 和β-CDP/ IBU的临界浓度固定为30 mg mL ？1 和35 mg mL ？1 。通过质子核磁共振（ 1 H NMR）和傅立叶变换红外光谱（FTIR），扫描电子显微镜（SEM），凝胶渗透色谱法对合成的高分子和水凝胶进行表征。 （GPC）和粉末X射线衍射仪（PXRD）。研究了凝胶-（β）CDP-HEC / IBU中IBU的溶胀研究和体外释放特性。结果表明，凝胶-（β）CDP-HEC / IBU中IBU的负载量为5 wt％，包裹在凝胶-（β）CDP-HEC / IBU中的IBU在1440分钟内具有缓释特性。另外，Korsmeyer-Peppas动力学模型与IBU的释放具有更好的相关性，并且释放过程是非菲克扩散过程。

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