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首页> 外文期刊>RSC Advances >Metabolomics reveal the protective effect of Farfarae Flos against asthma using an OVA-induced rat model
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Metabolomics reveal the protective effect of Farfarae Flos against asthma using an OVA-induced rat model

机译：代谢组学揭示了使用OVA诱导的大鼠模型，Farfarae Flos对哮喘的保护作用

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Farfarae Flos (FF) is widely used in china to treat pulmonary disorders such as coughs, bronchitis, tuberculosis and asthmatic disorders. In this study, a 1H NMR based metabolomic approach coupled with biochemical assay as well as histopathological inspection had been employed to study the protective effect of petroleum extracts of FF (PEFF) against OVA-induced asthma using a rat model. Multivariate analysis revealed that 19 of the perturbed endogenous metabolites in the lung could be reversed by PEFF, and MetPA analysis revealed that the anti-asthamtic effect of PEFF was probably related with regulation of arginine and proline metabolism, pyruvate metabolism and D-glutamine and D-glutamate metabolism. The regulatory effect on the cytokines (IL-4, IL-5, IL-13, and IL-17) and serum HO-1 suggested that the anti-asthmatic action of PEFF was also probably related with the balancing of the Th1/Th2 cells and the Nrf2/HO-1 pathway. The results of chemical analysis showed that the sesquiterpenes were present as the major components in PEFF, and further studies are needed to validate the bioactive compounds responsible for the anti-asthmatic effect of PEFF.
机译：Farfarae Flos（FF）在中国被广泛用于治疗肺部疾病，例如咳嗽，支气管炎，肺结核和哮喘。本研究采用基于 1 H NMR的代谢组学方法，结合生化分析和组织病理学检查，研究了FF石油提取物（PEFF）的保护作用。使用大鼠模型对抗OVA诱发的哮喘。多变量分析显示，PEFF可以逆转肺部扰动的19种内源性代谢产物，MetPA分析表明，PEFF的抗ast咽作用可能与精氨酸和脯氨酸代谢，丙酮酸代谢和 D < / small>-谷氨酰胺和 D -谷氨酸代谢。对细胞因子（IL-4，IL-5，IL-13和IL-17）和血清HO-1的调节作用表明，PEFF的抗哮喘作用也可能与Th1 / Th2的平衡有关细胞和Nrf2 / HO-1途径。化学分析的结果表明，倍半萜烯是PEFF的主要成分，还需要进一步的研究来验证负责PEFF抗哮喘作用的生物活性化合物。

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