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首页> 外文期刊>RSC Advances >Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects
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Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects

机译：生物测定指导下的 Magnolia biondii Pamp花芽中双环氧木聚糖的分离及其抗过敏作用

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摘要

The dried flower buds of Magnolia biondii Pamp (herbal name, Xin-Yi) are a traditional Chinese medicine with a long history of clinical use in the treatment of allergic rhinitis and sinusitis. However, the constituents responsible for its antiallergic effects remain unidentified. In the present study, a novel bisepoxylignan, isoeudesmin (1), and eight known bisepoxylignans, pluviatilol (2), eudesmin (3), magnolin (4), lirioresinol-B dimethyl ether (5), epimagnolin B (6), kobusin (7), aschantin (8), fargesin (9), were isolated from effective fractions through antiallergic bioassay-guided procedures using mouse bone marrow-derived mast cells (BMMCs) and IgE-induced passive cutaneous anaphylaxis mice. The compound structures were elucidated through nuclear magnetic resonance and mass spectrometry analyses. Compound 1 and compounds 2–6 and 9 exhibited antiallergic effects without affecting the viability of BMMCs. Compounds 2 and 9 showed the strongest effects with IC50 values of 52.18 and 93.03 μM, respectively. In this paper, the structure–activity relationship between these bisepoxylignans and their antiallergic effects is discussed. After evaluating the intensity of the antiallergic effects of the extracts, further separating the fractions, and isolating the purified compounds, we concluded that biosepoxylignans are the main constituents in Xin-Yi contributing to its anti-allergic efficacy.
机译： Magnolia biondii Pamp（药名，新沂）的干花蕾是中草药，在治疗变应性鼻炎和鼻窦炎方面具有悠久的临床历史。但是，负责其抗过敏作用的成分仍然不确定。在本研究中，一种新型的双环氧木脂素，异麦角蛋白（1）和八种已知的双环氧木脂素，丁草胺醇（2），芦丁素（3），厚朴素（4），鹅油树脂-B二甲醚（5），环氧甲酚B（6），kobusin （7），用小鼠骨髓源性肥大细胞（BMMC）和IgE诱导的被动性皮肤过敏反应小鼠，通过抗过敏性生物测定指导的程序从有效级分中分离了天冬氨酸（8），fargesin（9）。通过核磁共振和质谱分析阐明了化合物的结构。化合物1和化合物2-6和9表现出抗过敏​​作用，而不会影响BMMC的活力。化合物2和9表现出最强的作用，IC 50 值分别为52.18和93.03μM。在本文中，讨论了这些双环氧木脂素之间的构效关系及其抗过敏作用。在评估提取物的抗过敏作用强度，进一步分离各部分并分离纯化的化合物后，我们得出结论，生物环氧木脂素是信义中有​​助于其抗过敏功效的主要成分。

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