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首页> 外文期刊>RSC Advances >The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex
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The mode of antimicrobial action of curcumin depends on the delivery system: monolithic nanoparticles vs. supramolecular inclusion complex

机译：姜黄素的抗菌作用方式取决于递送系统：整体纳米颗粒 vs。超分子包合物

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Curcumin has been known for a long time for its antimicrobial properties that are further increased by exposure to light. Due to the low aqueous solubility of curcumin, appropriate delivery systems are required to facilitate its implementation. In this work, we compared the antimicrobial activity toward Escherichia coli of two curcumin formulations: methyl-β-cyclodextrin supramolecular inclusion complex and polyelectrolyte-coated monolithic nanoparticles. The two formulations showed disparity both in the extent and in the mode of toxicity, highlighting the distinct properties of materials at the nanoscale. The tests showed that while curcumin–β-cyclodextrin complexes exhibited a potent bactericidal activity, the curcumin nanoparticles were bacteriostatic. Illumination with blue light significantly increased the bactericidal efficacy of curcumin–cyclodextrin complexes but had limited influence on the activity of nanoparticulate curcumin. While the antimicrobial effect of the supramolecular complex was predominantly characterized by the increase in ROS and inhibition of electron transport, the primary attributes of the nanoparticle action were membrane depolarization and reduced ATP concentrations. Interestingly, the treatment with curcumin nanoparticles induced a filamentous phenotype of the bacterium. Our results suggest that the antimicrobial properties of curcumin depend upon a delivery formulation, which may have both practical and regulatory implications on the applicability and safety of curcumin nanomaterials.
机译：姜黄素因其抗菌性能而广为人知，该抗菌性能可通过暴露在光线下进一步增强。由于姜黄素的水溶性低，需要适当的递送系统以促进其实施。在这项工作中，我们比较了两种姜黄素制剂（甲基-β-环糊精超分子包合物和聚电解质包覆的整体纳米颗粒）对大肠杆菌的抗菌活性。两种制剂在毒性的程度和方式上均显示出差异，突出了纳米级材料的独特性能。测试表明，姜黄素-β-环糊精复合物显示出有效的杀菌活性，姜黄素纳米颗粒具有抑菌作用。蓝光显着提高了姜黄素-环糊精复合物的杀菌效果，但对纳米微粒姜黄素活性的影响有限。尽管超分子复合物的抗微生物作用主要以ROS的增加和电子传输的抑制为特征，但纳米粒子作用的主要属性是膜去极化和降低ATP浓度。有趣的是，用姜黄素纳米粒子处理可诱导细菌的丝状表型。我们的结果表明，姜黄素的抗微生物特性取决于递送制剂，这可能对姜黄素纳米材料的适用性和安全性都具有实际和监管意义。

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