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Biotransformation of dehydroepiandrosterone (DHEA) by environmental strains of filamentous fungi

机译：丝状真菌环境菌株对脱氢表雄酮（DHEA）的生物转化

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Microbial transformations of steroids are an important method of obtaining new steroid derivatives of potential pharmaceutical activity, which follows the principles of green chemistry. We studied the ability of selected filamentous fungus species to transform dehydroepiandrosterone (DHEA) and interesting DHEA derivatives were obtained. Twenty-five strains of filamentous fungi were isolated from soil and air in Wroclaw and they were used as biocatalysts. Strains of the genus Penicillium transformed the substrate into the products of Baeyer–Villiger lactonization in the D ring. Biotransformation of DHEA by Fusarium acuminatum KCh S1 strain led to a stereoselective hydroxylation at 7α (the product was obtained with 97% conversion). Androst-5-ene-3β,7α,17α-triol, compound with high anticancer activity towards glioblastoma and lymphoma cell lines was obtained with 65% yield in the culture of Mucor hiemalis KCh W2 strain. In the culture of Aspergillus versicolor KCh TJ1 strain, DHEA was transformed into androst-1,4-diene-3,17-dione (ADD) with high isolated yield.
机译：类固醇的微生物转化是获得具有潜在药物活性的新类固醇衍生物的重要方法，该方法遵循绿色化学原理。我们研究了所选丝状真菌种类转化脱氢表雄酮（DHEA）的能力，并获得了有趣的DHEA衍生物。在弗罗茨瓦夫从土壤和空气中分离出二十五个丝状真菌菌株，并将其用作生物催化剂。青霉菌属的菌株将底物转化为D环中的拜尔-维利格内酯化产物。 em镰孢KCh S1菌株对DHEA的生物转化导致7α处的立体选择性羟基化（产品转化率为97％）。在 Mhicor hiemalis KCh W2菌株培养物中获得了对成胶质细胞瘤和淋巴瘤细胞系具有高抗癌活性的化合物Androst-5-ene-3β，7α，17α-三醇。在杂色曲霉KCh TJ1菌株的培养中，DHEA以高分离产率转化为雄甾烯-1,4-二烯-3,17-二酮（ADD）。

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