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首页> 外文期刊>RSC Advances >Collagen modified with epoxidized safrole for improving antibacterial activity
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Collagen modified with epoxidized safrole for improving antibacterial activity

机译：用环氧化黄樟脑修饰的胶原蛋白可提高抗菌活性

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An epoxidized safrole, 5-(oxiran-2-ylmethyl)-benzo[d][1,3]dioxole (OYBD), was synthesized and employed to modify collagen for improving its antibacterial activity. The interaction between collagen and OYBD, and the structure/properties of the modified collagen were investigated in detail. The results indicated that the OYBD-modified collagen showed a higher de-nature temperature (Td, 90.2?°C), improved hydrophobic properties (contact angle from 84.2° to 89.1°) and enhanced tensile strength (6.2–11.0%) without destroying its triple helix structure. From observation of scanning electron microscopy (SEM), a higher density of intertwining morphology and a more stable network structure were observed, which was consistent with improved tensile strength and reduced breaking extension stress. The antibacterial test and LIVE/DEAD Baclight bacterial viability assay illustrated that the modified collagen exhibited excellent antibacterial activity to both Gram-negative and Gram-positive bacteria. Furthermore, the OYBD-modified collagen still exhibited cytocompatibility, supporting human fibroblast proliferation, which holds a great potential for developing antibacterial collagen-based biomaterials.
机译：合成了环氧化的黄樟脑5-（环氧乙烷-2-基甲基）-苯并[ d ] [1,3]二恶唑（OYBD），并用于修饰胶原蛋白以提高其抗菌活性。详细研究了胶原蛋白与OYBD之间的相互作用以及改性胶原蛋白的结构/性质。结果表明，OYBD改性的胶原蛋白显示出更高的变性温度（Td，90.2°C），改善的疏水性（接触角从84.2°至89.1°）和增强的拉伸强度（6.2-11.0％）而不会破坏它的三重螺旋结构。从扫描电子显微镜（SEM）的观察，观察到较高的缠结形态密度和更稳定的网络结构，这与提高的拉伸强度和降低的断裂延伸应力相一致。抗菌测试和LIVE / DEAD Baclight细菌生存力分析表明，改性后的胶原蛋白对革兰氏阴性和革兰氏阳性细菌均表现出优异的抗菌活性。此外，OYBD修饰的胶原蛋白仍表现出细胞相容性，支持人类成纤维细胞增殖，这在开发基于抗菌胶原蛋白的生物材料方面具有巨大潜力。

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