Polypyrrole-modified CuS nanoprisms for efficient near-infrared photothermal therapy

Ruiyang Zhao; Xiaoxia Sun; Jing Sun; Lei Wang; Jishu Han

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Polypyrrole-modified CuS nanoprisms for efficient near-infrared photothermal therapy

机译：聚吡咯修饰的CuS纳米棱镜用于有效的近红外光热疗法

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The application of functional nanomaterials in cancer therapy has become a new developing trend due of their unique size-dependent physicochemical performance. In this study, CuS nanoprisms were fabricated via a seed-mediated growth method. The as-prepared CuS nanoprisms possessed a more intense near-infrared absorption at 1184?nm compared with other morphologies. CuS nanoprisms were modified with a polypyrrole (PPy) shell on the surface through oxidative polymerization. The PPy shell efficiently decreased the nanocomposite cytotoxicity and increased the biocompatibility. Based on the excellent photothermal conversion performance of CuS-PPy nanoprisms, the cancer cells in vitro could be killed effectively and the tumor in vivo could be cured through photothermal therapy. This indicated that CuS-PPy nanoprisms are able to be used as an efficient theranostic agent for tumor photothermal therapy in the future.

机译：功能纳米材料在癌症治疗中的应用由于其独特的尺寸依赖性理化性能而成为一种新的发展趋势。在这项研究中，通过种子介导的生长方法制备了CuS纳米棱镜。所制备的CuS纳米棱镜与其他形态相比，在1184nm处具有更强的近红外吸收。 CuS纳米棱镜在表面通过聚吡咯（PPy）壳进行了氧化聚合反应。 PPy外壳有效地降低了纳米复合材料的细胞毒性，并提高了生物相容性。基于CuS-PPy纳米棱镜优异的光热转化性能，可以通过光热疗法有效杀死体外癌细胞，并治愈体内肿瘤。这表明CuS-PPy纳米棱镜将来可以用作肿瘤光热疗法的有效治疗剂。 展开▼

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《RSC Advances》 |2017年第17期|共7页

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Ruiyang Zhao; Xiaoxia Sun; Jing Sun; Lei Wang; Jishu Han;
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中图分类化学;

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Polypyrrole-modified CuS nanoprisms for efficient near-infrared photothermal therapy

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