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首页> 外文期刊>RSC Advances >Serum metabolomics strategy for understanding the therapeutic effects of Yin-Chen-Hao-Tang against Yanghuang syndrome
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Serum metabolomics strategy for understanding the therapeutic effects of Yin-Chen-Hao-Tang against Yanghuang syndrome

机译：血清代谢组学策略，以了解茵陈蒿汤对羊黄综合症的治疗作用

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Yin-Chen-Hao-Tang (YCHT), a classic Chinese herbal formula, is characterized by its strong therapeutic effects of liver regulation and relief of jaundice, especially Yanghuang syndrome (YHS). YHS is a type of jaundice with damp-heat pathogenesis, and it is considered a complicated Chinese medicine syndrome (CMS). The accurate mechanism for healing YHS has not yet been completely reported. The purpose of the current research is to investigate the expression of endogenous biomarkers in YHS mice and evaluate the clinical therapeutic effect of YCHT. Serum samples were analyzed using UPLC-Q/TOF-MS techniques in order to determine differential metabolites to elucidate the functional mechanism of YCHT on YHS through metabolite profiling combined with multivariate analysis. Simultaneously, the exact diversification of YHS mice was elucidated using blood biochemistry indexes and histopathological examination, and the results indicated that YHS is markedly improved by YCHT. Unsupervised principal component analysis (PCA) patterns were constructed to dissect the variances of metabolic profiling. Overall, 22 potential biomarkers were identified using a metabolomics approach based on an accurate MS/MS approach, clustering and distinguishing analysis. The present work demonstrates that the effectiveness of YCHT against YHS prompts distinct discrepancies in metabolic profiles by adjusting biomarkers and regulating metabolic disorders. A total of 15 metabolic pathways were involved in biological disturbance. This demonstrates that metabolomic techniques are powerful means to explore the pathogenesis of CMS and the therapeutic effects of traditional Chinese formulae.
机译：阴陈好汤（YCHT）是一种经典的中草药配方，其特点是对肝脏具有调节作用，可减轻黄疸，尤其是黄黄综合症（YHS），具有很强的治疗作用。 YHS是一种黄热病，具有湿热致病机理，被认为是一种复杂的中医综合症。尚未完全报道治愈YHS​​的确切机制。当前研究的目的是研究内源性生物标志物在YHS小鼠中的表达并评估YCHT的临床治疗效果。使用UPLC-Q / TOF-MS技术分析血清样品，以确定差异代谢物，以通过代谢物谱分析和多变量分析阐明YCHT对YHS的功能机制。同时，通过血液生化指标和组织病理学检查阐明了YHS小鼠的确切多样性，结果表明YCHT显着改善了YHS。构造无监督主成分分析（PCA）模式以剖析代谢谱的差异。总体而言，使用代谢组学方法基于准确的MS / MS方法，聚类和区分分析，鉴定出22种潜在的生物标志物。本工作表明，YCHT对YHS的有效性可通过调节生物标志物和调节代谢紊乱来促进代谢谱中的明显差异。共有15种代谢途径参与了生物干扰。这表明代谢组学技术是探索CMS发病机理和中药配方治疗作用的有力手段。

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