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首页> 外文期刊>RSC Advances >Gadolinium-labelled iron/iron oxide core/shell nanoparticles as T1–T2 contrast agent for magnetic resonance imaging
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Gadolinium-labelled iron/iron oxide core/shell nanoparticles as T1–T2 contrast agent for magnetic resonance imaging

机译：d标记的铁/氧化铁核/壳纳米粒子作为T1-T2造影剂用于磁共振成像

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Magnetic resonance imaging (MRI) is indispensable and powerful in modern clinical diagnosis and has some advantages such as non-invasiveness and high penetration depth. Furthermore, dual T _(1) – T _(2) MR imaging has attracted crucial interest as it can decrease the risk of pseudo-positive signals in diagnosing lesions. And it's worth nothing that the dual-mode MR imaging displays a vital platform to provide relatively comprehensive diagnosis information and receive accurate results. Herein, we report a dual T _(1) – T _(2) MR imaging contrast agent (CA) grounded on the iron/iron oxide core/shell nanomaterials conjugated with gadolinium chelate. The Gd-labeled Fe@Fe _(3) O _(4) NPs reveal the feasibility to utilize them to serve as a dual T _(1) – T _(2) MR imaging CA, and the relaxivity results in a 0.5 T MR system showed a longitudinal relaxivity value ( r _(1) ) and transverse relaxivity value ( r _(2) ) of 7.2 mM ~(?1) s ~(?1) and 109.4 mM ~(?1) s ~(?1) , respectively. The MTT results demonstrate the Gd-labeled Fe@Fe _(3) O _(4) NPs have no obvious cytotoxicity and a good compatibility. The in vitro and in vivo MRI generated a brighter effect and darkening in T _(1) -weighted MR imaging and T _(2) -weighted images, respectively. The results clearly indicate that Gd-labeled Fe@Fe _(3) O _(4) NPs have potential as a magnetic resonance imaging contrast reagent.
机译：磁共振成像（MRI）在现代临床诊断中必不可少且功能强大，并具有无创性和高穿透深度等优点。此外，双重T _（1）– T _（2）MR成像引起了人们的极大兴趣，因为它可以降低诊断病变时假阳性信号的风险。而且，双模MR成像显示一个至关重要的平台来提供相对全面的诊断信息并获得准确的结果是毫无价值的。在这里，我们报告双T _（1）– T _（2）MR成像造影剂（CA）接地在与/螯合物共轭的铁/氧化铁核/壳纳米材料上。 Gd标记的Fe @ Fe _（3）O _（4）NP揭示了将它们用作双重T _（1）– T _（2）MR成像CA的可行性，弛豫度为0.5 T MR系统的纵向弛豫值（r _（1））和横向弛豫值（r _（2））分别为7.2 mM〜（？1）s〜（？1）和109.4 mM〜（？1）s〜 （？1）。 MTT结果表明，Gd标记的Fe @ Fe _（3）O _（4）NPs没有明显的细胞毒性和良好的相容性。体外和体内MRI分别在T_（1）加权MR成像和T_（2）加权成像中产生了更亮的效果和更暗的效果。结果清楚地表明，Gd标记的Fe @ Fe _（3）O _（4）NPs具有作为磁共振成像造影剂的潜力。

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