Flow synthesis of secondary amines over Ag/Al<sub>2</sub>O<sub>3</sub> catalyst by one-pot reductive amination of aldehydes with nitroarenes

Ekaterina A. Artiukha; Alexey?L. Nuzhdin; Galina A. Bukhtiyarova; Valerii I. Bukhtiyarov

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Flow synthesis of secondary amines over Ag/Al₂O₃ catalyst by one-pot reductive amination of aldehydes with nitroarenes

机译：Ag / Al _{2 O _{3 催化剂上的硝基芳烃一锅还原胺化流化合成仲胺}}

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An alumina-supported silver catalyst was investigated in the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor using molecular hydrogen as a reducing agent. A series of secondary amines containing alkyl, OH, OCH₃, Cl, Br and CC groups was synthesized in good to excellent yields. The yield of the secondary amine depends on the rate of formation of an intermediate imine. It was shown that the accumulation of carbonaceous deposits on the catalyst is the main reason of catalyst deactivation. The spent catalyst can be easily regenerated and reused without losing catalytic activity.

机译：在使用分子氢作为还原剂的连续流动反应器中，用硝基芳烃对醛进行一锅还原胺化研究了氧化铝负载的银催化剂。合成了一系列含有烷基，OH，OCH _{3 ，Cl，Br和CC基团的仲胺，收率良好。仲胺的产率取决于中间体亚胺的形成速率。结果表明，碳质沉积物在催化剂上的积累是催化剂失活的主要原因。废催化剂可以容易地再生和再利用而不会失去催化活性。}

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《RSC Advances》 |2017年第72期|共6页
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Ekaterina A. Artiukha; Alexey?L. Nuzhdin; Galina A. Bukhtiyarova; Valerii I. Bukhtiyarov;
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中图分类化学;
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1. Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes [J] . Artiukha Ekaterina A., Nuzhdin Alexey L., Bukhtiyarovaa Galina A., RSC Advances . 2017,第72期

机译：用硝基醛一盆栽还原胺对Ag / Al2O3催化剂流动合成仲胺
2. Flow synthesis of secondary amines over Ag/Al₂O₃ catalyst by one-pot reductive amination of aldehydes with nitroarenes [J] . Ekaterina A. Artiukha, Alexey?L. Nuzhdin, Galina A. Bukhtiyarova, RSC Advances . 2017,第72期

机译：Ag / Al _{2 O _{3 催化剂上的硝基芳烃一锅还原胺化流化合成仲胺}}
3. Synthesis of secondary amines by reductive amination of aldehydes with nitroarenes over supported copper catalysts in a flow reactor [J] . Alexey L. Nuzhdin, Ekaterina A. Artiukha, Galina A. Bukhtiyarova, Catalysis Communications . 2017,第期

机译：通过在流动反应器中用醛与硝基丙酮醛的还原胺化合成仲胺
4. Direct asymmetric Michael reaction of α,β-unsaturated aldehydes and ketones catalyzed by two secondary amine catalysts [C] . Umekubo Nariyoshi, Terunuma Takahiro, Hayashi Yujiro 日本化学会春季年会講演予稿集 . 2018

机译：由两个仲胺催化剂催化的α，β-不饱和醛和酮的直接不对称迈克尔反应
5. Part I. Asymmetric organocatalysis: (1) Direct enantioselective organocatalytic hydroxymethylation of aldehydes catalyzed by alpha,alpha-diphenylprolinol trimethylsilyl ether: Application in the formal synthesis of (-)-Rasfonin; (2) Synthesis of a novel bicyclic secondary amine organocatalyst: Application to the direct enantioselective organocatalytic hydroxymethylation of aldehydes. Part II. Asymmetric synthesis of bicyclic analogues of the anti-osteoporotic drug risedronate. [D] . Miller, John Robert. 2010

机译：第一部分，不对称有机催化：（1）α，α-二苯基脯氨醇三甲基甲硅烷基醚催化的醛的直接对映选择性有机催化羟甲基化：在（-）-Rasfonin的正式合成中的应用；（2）新型双环仲胺有机催化剂的合成：应用于醛的直接对映选择性有机催化羟甲基化。第二部分抗骨质疏松药物Risedronate的双环类似物的不对称合成。
6. A One-Pot Selective Synthesis of N-Boc Protected Secondary Amines: Tandem Direct Reductive Amination/N-Boc Protection [O] . Raghupathi Neelarapu, Pavel A. Petukhov -1

机译：N-BOC保护仲胺的单罐选择性合成：串联直接还原胺化/ N-BOC保护
7. One-pot reductive amination of aldehydes with nitroarenes over an Au/Al2O3 catalyst in a continuous flow reactor [O] . E. A. Artiukha, A. L. Nuzhdin, G. A. Bukhtiyarova, 2015

机译：在连续流动反应器中通过Au / Al2O3催化剂在Au / Al 2 O 3催化剂上用醛醛醛胺化醛

Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

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Flow synthesis of secondary amines over Ag/Al₂O₃ catalyst by one-pot reductive amination of aldehydes with nitroarenes