Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

Asim Halder; Suvadra Das; Tanmoy Bera; Arup Mukherjee

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Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

机译：山萘酚中单分散金纳米颗粒的快速合成及其对野生和耐药菌株的抗leishmanial功效

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Leishmaniasis is a WHO notified neglected tropical disease (NTD) caused by the Leishmania parasite species. The parasite locates rapidly in the macrophage cells and survives there for a long period of time with or without any symptomatic response. Eliminating Leishmania from the macrophage sites is complicated. Only a few antileishmanial drugs are known and most of them have developed resistance over the time. We have synthesized highly monodispersed gold nanoparticles (KAunp) in a rapid reduction reaction catalyzed in kaempferol. Kaempferol stabilized nanoparticles in 18.24 nm size domain were used as leishmanicidals in macrophage infested conditions. KAunps' CC₅₀ in the macrophages was at 2.4 × 102 μM while that for sodium stibogluconate was 27 μM. Phagocytic uptake in infested cells was fast and remarkable. KAunps were explicitly effective against both the wild and drug resistant organisms. Monodispersed gold nanoparticles synthesized in green technology appeared as safer alternatives for leishmanial chemotherapy.

机译：利什曼病是世界卫生组织（WHO）通知的由 Leishmania 寄生虫物种引起的被忽视的热带病（NTD）。寄生虫在巨噬细胞中迅速定位，并在有或无任何症状反应的情况下在其中存活很长一段时间。从巨噬细胞部位消除利什曼原虫很复杂。仅有几种抗衰老药物是已知的，并且随着时间的推移，大多数药物已产生抗药性。我们已经在kaempferol催化的快速还原反应中合成了高度单分散的金纳米颗粒（KAunp）。在巨噬细胞侵染条件下，在18.24 nm尺寸域中由山奈酚稳定的纳米颗粒用作杀利虫剂。 KAunps在巨噬细胞中的CC _{50 为2.4×10 2 μM，而司他葡糖酸钠的CC _{50 为27μM 。受侵染细胞吞噬细胞的速度非常快。 KAunps对野生生物和耐药生物均具有显着效果。用绿色技术合成的单分散金纳米颗粒似乎是利什曼瘤化学疗法的更安全替代品。}} 展开▼

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《RSC Advances》 |2017年第23期|共9页

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Asim Halder; Suvadra Das; Tanmoy Bera; Arup Mukherjee;
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中图分类化学;

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机译：一种简便的一锅快速合成方法，用于开发适度单分散和稳定的球形金纳米颗粒

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机译：一锅合成金纳米颗粒及其在野生型和耐药型内脏利什曼病的化疗中的应用

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机译：生物分子官能化银纳米粒子的快速单盆绿色合成及其对蚕的多药抗性（MDR）肠道（Bombyx Mori）的疗效

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机译：抗药性和野生型菌株相互作用：研究转化延迟对可能的控制策略的影响

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机译：通过一氧化碳还原进行尺寸控制的单分散金纳米颗粒的合成。

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机译：野生和耐药性利什曼原虫donovani Amastigote阶段对穿心莲内酯纳米粒子的体外药敏性：维生素E衍生物TPGS在纳米粒子功效中的作用

7. Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains [O] . Asim Halder, Suvadra Das, Tanmoy Bera, 2017

机译：在Kaempferolol和抗利什法尼的单分散金纳米粒子的快速合成抗野生和耐药菌株

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机译：单步法溴化合成单掺杂金纳米粒子的工艺

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机译：通过减少一氧化碳气体的大小控制合成单分散的金纳米粒子

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Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

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