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Changing the shape of hair with keratin peptides

机译：用角蛋白肽改变头发的形状

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Chemical straightening of curly human hair fibres involves the use of strong reducing agents at alkaline pH. Human hair is made of keratin, and the fixation of fibre shape involves the reduction and reformation of new disulphide bonds between keratin molecules. Here, we propose an alternative and green methodology using keratin peptide sequences (10–13 residues) derived from the human genome. In a previous study, we analysed 1235 cysteine-containing peptides encoded by all human genes of hair keratin and keratin-associated proteins. These peptide fragments have been designed by nature to interact with keratin. Here we tested eight peptides, which were select based on their affinity for human hair keratin solution as shown by Matrix-Assisted Laser-Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF/TOF) and by molecular dynamics simulation. The peptides were characterized in detail regarding their ability to act as hair straightening modulators and to improve the tensile strength and elasticity of hair. Of the eight tested peptides, PepE, PepG and KP showed the highest ability to interact with a keratin peptide model, and to improve hair mechanical properties and straightening efficiency. The proposed solutions presented here will replace harsh reducing agents at alkaline pH by peptide formulations acting at neutral pH to change hair shape through the re-conformation of disulphide bonds. Here, we provide experimental evidence which explains at a molecular level how keratin decapeptides can interact with large keratin molecules in human hair, opening an innovative green approach to changing the shape of hair fibre.
机译：人发卷曲纤维的化学拉直涉及在碱性pH下使用强还原剂。人的头发由角蛋白制成，纤维形状的固定涉及角蛋白分子之间新的二硫键的还原和再形成。在这里，我们提出了一种替代的绿色方法，该方法使用了来自人类基因组的角蛋白肽序列（10-13个残基）。在先前的研究中，我们分析了由头发角蛋白和角蛋白相关蛋白的所有人类基因编码的1235个含半胱氨酸的肽。这些肽片段已被自然界设计为与角蛋白相互作用。在这里，我们测试了八种肽，这些肽是根据它们对人发角蛋白溶液的亲和力进行选择的，如基质辅助激光解吸电离飞行时间质谱（MALDI-TOF / TOF）和分子动力学模拟所示。对其肽作为头发拉直调节剂和改善头发的拉伸强度和弹性的能力进行了详细表征。在八种测试的肽中，PepE，PepG和KP显示出与角蛋白肽模型相互作用以及改善毛发机械性能和拉直效率的最高能力。本文提出的解决方案将通过在中性pH下起作用的肽制剂代替碱性pH下的刺激性还原剂，从而通过二硫键的重新构型来改变头发的形状。在这里，我们提供了实验证据，从分子水平上解释了角蛋白十肽如何与人发中的大角蛋白分子相互作用，从而为改变头发纤维的形状开辟了一种创新的绿色方法。

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