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首页> 外文期刊>RSC Advances >Evaluation of the protective effects of 13 traditional Chinese medicine compounds on ionizing radiation injury: bupleurum, shenmai, and breviscapine as candidate radioprotectors
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Evaluation of the protective effects of 13 traditional Chinese medicine compounds on ionizing radiation injury: bupleurum, shenmai, and breviscapine as candidate radioprotectors

机译：评价13种中药化合物对电离辐射损伤的保护作用：短发，神麦和灯盏花素作为候选放射防护剂

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Background: Drugs are being sought that are effective as radioprotection for use in both planned and unplanned radiation exposure. Traditional Chinese medicines have been used successfully for the treatment of free radical-mediated diseases and therefore we expected that exploring such agents could yield an effective radioprotector. We therefore evaluated the radioprotective effects of 13 traditional Chinese medicine compounds (TCMCs) against ionizing radiation damage. Materials and methods: TCMCs were tested in vitro on human kidney 293T cells treated with 0, 2, 4, 6, 8 or 10 Gy irradiation for their ability to promote cell survival. Mice were subjected to a sub-lethal (4 Gy), lethal (7 Gy) or supra-lethal (13 Gy) dose of total-body irradiation (TBI) and TCMCs were tested for their ability to influence survival and hemopoietic function. Results: Of the 13 TCMCs tested, five including bupleurum, shenmai, and breviscapine, promoted survival of 293T cells. bupleurum, shenmai, and breviscapine also prolonged survival times of mice treated with supra-lethal and lethal TBI doses. As expected of an effective radioprotector, they also ameliorated bone marrow suppression, reducing the decrease in bone marrow cells after sub-lethal TBI, and they attenuated the TBI-induced reduction in granulocyte-macrophage colony-forming units. Conclusion: This investigation of TCMCs in vitro and in vivo identified bupleurum, shenmai, and breviscapine as having characteristics consistent with radioprotective agents. Further investigation to identify the bioactive components responsible for the radioprotective effect of these compounds is now required.
机译：背景：正在寻求能有效用作放射防护的药物，用于计划内和计划外的辐射暴露。中药已成功用于治疗自由基介导的疾病，因此我们希望探索此类药物可以产生有效的辐射防护剂。因此，我们评估了13种中药化合物（TCMC）对电离辐射损伤的辐射防护作用。 材料和方法：TCMCs在接受0、2、4、6、8或10 Gy辐射的人肾293T细胞上进行了体外测试，这些细胞具有促进细胞存活的能力。对小鼠进行亚致死剂量（4 Gy），致死剂量（7 Gy）或超致死剂量（13 Gy）的全身照射（TBI），并测试TCMC影响存活和造血功能的能力。 结果：在所测试的13台TCMC中，包括布普鲁姆，神麦和灯盏花素在内的5种TCMC促进了293T细胞的存活。布普鲁姆，神麦和灯盏花素也可延长用超致死和致死量TBI剂量治疗的小鼠的存活时间。如预期的有效放射防护剂一样，它们还改善了骨髓抑制作用，减少了亚致死性TBI后骨髓细胞的减少，并且减弱了TBI诱导的粒细胞-巨噬细胞集落形成单位的减少。 结论：这项对TCMC体外和体内的调查确定了短梗，神麦和灯盏花素具有与放射防护剂一致的特征。现在需要进一步研究以鉴定负责这些化合物的辐射防护作用的生物活性成分。

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