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首页> 外文期刊>RSC Advances >Molecular and chemotypic variability of forskolin in Coleus forskohlii Briq., a high value industrial crop collected from Western Himalayas (India)
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Molecular and chemotypic variability of forskolin in Coleus forskohlii Briq., a high value industrial crop collected from Western Himalayas (India)

机译：取自西喜马拉雅山（印度）的高价值工业作物 Coleus forskohlii Briq。中毛喉素的分子和化学型变异性

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C. forskohlii (willd.) Briq. is an industrially viable medicinal crop and is widely exploited for the therapeutic potential of its bioactive metabolite, forskolin. The present investigation aimed to explore the chemotypic variability of forskolin content and existing molecular diversity in the wild population of C. forskohlii from the Western Himalayan region of India. Twelve germplasm(s) from different populations were assessed for molecular fingerprinting (ISSR marker) and densitometeric quantification of forskolin. Two elite germplasms viz. NBC-24 (0.728%) and NBC-16 (0.641%) were obtained as the highest accumulator of forskolin with high genetic variability (92%). The UPGMA hierarchical clustering patterns revealed strong genetic grouping between the individuals corresponding to their geographical ranges. Mantel tests showed positive correlation (r = 0.354, p = 0.003) between molecular and chemical fingerprints that reflects the feasibility of the ISSR markers in analyzing genome information related to forskolin biosynthesis from varied phytogeography. Pearson correlation coefficient (0.102) between forskolin content with altitude gradient also denoted a positive correlation. However, the association of both genetic and chemical fingerprinting data with the geographic distance matrix was apparently negative (r = ?0.234, p = 0.054; r = ?0.067, p = 0.584) which meant that distance might be a predictor of population differentiation. Our study signifies the utility of metabolic and molecular fingerprints for identification of elite accessions and provides a lead to industry for commercial exploitability of Coleus species including its location specific commercial cultivation.
机译： C。 forskohlii （愿意）。是一种工业上可行的药用作物，因其生物活性代谢物福斯高林的治疗潜力而被广泛开发。本研究旨在探讨福斯科林含量的化学型变异性和 C野生种群中现有的分子多样性。来自印度西喜马拉雅地区的forskohlii 。对来自不同种群的十二个种质进行了分子指纹分析（ISSR标记）和福斯克林的光密度定量分析。获得了两个最佳种质 viz。 NBC-24（0.728％）和NBC-16（0.641％），作为福斯科林的最高积累者，具有较高的遗传变异性（92％）。 UPGMA层次聚类模式揭示了个体之间对应其地理范围的强大遗传分组。壁炉架测试显示分子指纹和化学指纹之间呈正相关（ r = 0.354， p = 0.003），这反映了ISSR标记在分析与毛喉素生物合成有关的基因组信息方面的可行性。不同的植物地理。福斯科林含量与海拔梯度之间的皮尔森相关系数（0.102）也表示为正相关。但是，遗传和化学指纹数据与地理距离矩阵的关联显然为负（ r = 0.234， p = 0.054; r =？0.067， p = 0.584），这意味着距离可能是人口分化的预测指标。我们的研究标志着代谢和分子指纹图谱在鉴定优良种质中的实用性，并为锦蛇物种的商业可利用性（包括其特定位置的商业种植）提供了产业线索。

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