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首页> 外文期刊>RSC Advances >Synthesis and characterization of near-infrared-emitting CdHgTe/CdS/ZnS quantum dots capped by N-acetyl-L-cysteine for in vitro and in vivo imaging
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Synthesis and characterization of near-infrared-emitting CdHgTe/CdS/ZnS quantum dots capped by N-acetyl-L-cysteine for in vitro and in vivo imaging

机译：被 N -乙酰基-L-半胱氨酸封端的近红外发射CdHgTe / CdS / ZnS量子点的合成和表征，用于体外和体内成像

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In this article, highly photoluminescent near-infrared (NIR)-emitting quantum dots (QDs) were directly synthesized in water by a fast, inexpensive and facile method. Unlike the conventional technique, biocompatible N-acetyl-L-cysteine (NAC) capped CdHgTe/CdS core/shell QDs were successfully synthesized through a one-pot sequential growth of the core and shell in a controlled manner. An additional ZnS shell was deposited around the outer layer of CdHgTe/CdS QDs to render the core/shell/shell QDs less sensitive to environmental changes and less toxic to living bodies. The experimental results from high resolution transmission electron microscopy and X-ray powder diffraction indicated the as-prepared QDs have a very small diameter and good monodispersity. Furthermore, the CdHgTe/CdS/ZnS core/shell/shell QDs were successfully applied for in vitro imaging, and the results demonstrated that the biocompatible NIR QDs exhibited highly spectrally and spatially resolved imaging. Moreover, the NAC capped QDs were directly used for in vivo tumor targeting of nude mice by passive targeting. The tumor was identified distinctly by the ultra-small QDs within only 2?h of blood circulation. Through the leakiness of the tumor vasculature, the QDs showed excellent accumulation in the tumor region for as long as 4 h. The results of acute toxicity tests showed that the biocompatible NIR QDs caused negligible harmful effects to the nude mice at experimental dosages, indicating that the high fluorescence probes can be highly effective in long-term diagnostics and therapy in in vivo observation.
机译：在本文中，通过快速，廉价和简便的方法在水中直接合成了高光致发光近红外（NIR）发射量子点（QD）。与传统技术不同，生物相容性 N -乙酰基- L -半胱氨酸（NAC）封端的CdHgTe / CdS核/壳量子点通过一锅连续生长成功合成。核心和外壳以受控方式运行。在CdHgTe / CdS量子点的外层周围沉积了另外的ZnS壳层，以使核/壳/壳层量子点对环境变化较不敏感，对生物体的毒性也较小。高分辨率透射电子显微镜和X射线粉末衍射的实验结果表明，所制备的量子点具有非常小的直径和良好的单分散性。此外，CdHgTe / CdS / ZnS核/壳/壳量子点已成功应用于体外成像，结果表明，生物相容性近红外量子点具有高光谱和空间分辨成像性能。此外，NAC封端的量子点通过被动靶向直接用于裸鼠的体内肿瘤靶向。仅在血液循环2小时内就通过超小型QD明确识别了肿瘤。通过肿瘤脉管系统的渗漏，这些量子点在长达4 h的肿瘤区域表现出极好的积累。急性毒性试验结果表明，在实验剂量下，生物相容性近红外定量量子点对裸鼠的有害影响可忽略不计，这表明高荧光探针在体内的长期诊断和治疗中可以非常有效。 >观察。

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