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首页> 外文期刊>RSC Advances >An environmentally benign approach to achieving vectorial alignment and high microporosity in bacterial cellulose/chitosan scaffolds
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An environmentally benign approach to achieving vectorial alignment and high microporosity in bacterial cellulose/chitosan scaffolds

机译：在细菌纤维素/壳聚糖支架中实现矢量比对和高微孔性的环保方法

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Bacterial cellulose (BC) nanofibers secreted by Komagataeibacter xylinus 10245 were applied alone or in combination with chitosan to prepare highly aligned and porous scaffolds through a combined liquid nitrogen-initiated ice “templating” and freeze-drying process. Their morphology and physical properties were controlled by adjusting the concentration of chitosan over a range of 1, 1.5, and 2% (wt%) and analyzed by Scanning Electron Microscopy (SEM), Brunauer–Emmett–Teller (BET), and X-ray diffraction methods. The SEM images confirmed a distribution of fibrils vectorially aligned in the freezing axis direction, while chitosan contributed to the development of a dense network, superior mechanical properties, and biomedical relevance of the final scaffolds. It was found that as the chitosan concentration increased, the crystallinity index decreased from 89% to 79% likely because of strong intermolecular bonding. However, the scaffolds containing chitosan demonstrated excellent shape recovery and structural stability after compressive tests and may act as excellent scaffolds for potential cartilage tissue engineering applications.
机译：由 Komagataeibacter xylinus 10245分泌的细菌纤维素（BC）纳米纤维可单独使用，也可与壳聚糖结合使用，通过液氮引发的冰“模板化”和冷冻干燥过程来制备高度排列的多孔支架。通过调节壳聚糖浓度在1、1.5和2％（wt％）范围内来控制其形态和物理性能，并通过扫描电子显微镜（SEM），Brunauer-Emmett-Teller（BET）和X-射线衍射法。 SEM图像证实了在冷冻轴方向上矢量排列的原纤维的分布，而壳聚糖有助于最终骨架的致密网络的发展，优异的机械性能和生物医学相关性。发现随着壳聚糖浓度的增加，结晶度指数可能由于强的分子间键合而从89％降低至79％。然而，含有壳聚糖的支架在压缩测试后显示出优异的形状恢复和结构稳定性，并且可以作为潜在软骨组织工程应用的优良支架。

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