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首页> 外文期刊>RSC Advances >Sensing of hydrogen peroxide and glucose in human serum via quenching fluorescence of biomolecule-stabilized Au nanoclusters assisted by the Fenton reaction
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Sensing of hydrogen peroxide and glucose in human serum via quenching fluorescence of biomolecule-stabilized Au nanoclusters assisted by the Fenton reaction

机译：通过Fenton反应辅助生物分子稳定的金纳米团簇的猝灭荧光检测人血清中的过氧化氢和葡萄糖

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摘要

Fe2+ can act as a catalyst to disproportionate hydrogen peroxide (H2O2) to produce extremely reactive hydroxyl radicals (˙OH) through the so-called Fenton reaction. Combining this reaction with the prominent sensitive nature of gold nanoclusters (Au NCs), we present herein a simple strategy of sensitive and rapid detection of H2O2. Compared with H2O2, the produced hydroxyl radical exhibits a much stronger oxidizing ability, and therefore could lead to a more efficient oxidation of the Au NCs and an improved sensitivity and oxidation rate. The results indicate that the detection limit for the determination of H2O2 was 0.2 μM (signaloise = 3) and the linear range was 0.4–12 μM. Furthermore, in combination with the specific catalytic effect of glucose oxidase, the present sensing strategy can be successfully expanded to detect glucose in blood. The preliminary results are in good agreement with those provided by the hospital, which suggests the generalizability and great potential of the Au NCs/Fenton hybrid system for research and clinical diagnosis of diabetes.
机译：Fe 2 + 可以充当过氧化氢歧化的催化剂（H 2 O 2 ）通过所谓的Fenton反应产生极高反应性的羟基自由基（˙OH）。结合该反应与金纳米团簇（Au NCs）的显着敏感性，我们在本文中提出了一种灵敏，快速检测H 2 O 2 。与H 2 O 2 相比，生成的羟基具有更强的氧化能力，因此可能导致可以更有效地氧化Au NCs，并提高灵敏度和氧化速率。结果表明，测定H 2 O 2 的检测限为0.2μM（信号/噪声= 3），线性范围为0.4–12μM。此外，结合葡萄糖氧化酶的特定催化作用，可以成功地扩展本发明的传感策略以检测血液中的葡萄糖。初步结果与医院提供的结果吻合良好，这表明Au NCs / Fenton混合系统在糖尿病研究和临床诊断中具有普遍性和巨大潜力。

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