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首页> 外文期刊>RSC Advances >Bifunctional cationic solid lipid nanoparticles of β-NaYF4:Yb,Er upconversion nanoparticles coated with a lipid for bioimaging and gene delivery
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Bifunctional cationic solid lipid nanoparticles of β-NaYF4:Yb,Er upconversion nanoparticles coated with a lipid for bioimaging and gene delivery

机译：β-NaYF 4 ：Yb，Er上转换双功能阳离子固体脂质纳米粒包覆脂质用于生物成像和基因传递

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β-NaYF4:Yb,Er upconversion nanoparticles (UCNPs) were synthesized by a one-pot solvothermal method. The UCNPs were characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to prove that they possessed hexagonal crystal phase with uniform particle size distribution. The cationic solid lipid nanoparticles (CSLNs) were then obtained by coating the UCNPs with a lipid. Further analysis by FTIR, XRD and TEM indicated the lipid can successfully coat UCNPs, and the coating process had no obvious influences on morphology and crystallization of the UCNPs. Furthermore, the CSLNs were used for bioimaging in cells and delivering small interfering RNA (siRNA). Cellular bioimaging and upconversion luminescence studies clearly demonstrated that the CSLNs could effectively enter into cells with the help of the lipid. Silencing assays and cytotoxicity in A549 cells convincingly showed that the CSLNs could effectively deliver siRNA and possessed low cytotoxicity and good biocompatibility. Thus, the bifunctional CSLNs could be used as a potential candidate in bioimaging and therapeutic applications.
机译：用一锅溶剂热法合成了β-NaYF 4 ：Yb，Er上转换纳米粒子（UCNPs）。通过X射线衍射（XRD），扫描电子显微镜（SEM）和透射电子显微镜（TEM）对UCNPs进行表征，以证明它们具有粒径分布均匀的六方晶相。然后通过用脂质包被UCNP来获得阳离子固体脂质纳米颗粒（CSLN）。 FTIR，XRD和TEM的进一步分析表明脂质可以成功地包被UCNPs，包被过程对UCNPs的形态和结晶没有明显的影响。此外，CSLN被用于细胞中的生物成像并传递小的干扰RNA（siRNA）。细胞生物成像和上转换发光研究清楚地表明，CSLNs可以在脂质的帮助下有效进入细胞。令人信服的A549细胞沉默试验和细胞毒性表明，CSLNs可以有效地递送siRNA，并且具有低细胞毒性和良好的生物相容性。因此，双功能CSLNs可以用作生物成像和治疗应用中的潜在候选人。

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