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首页> 外文期刊>RSC Advances >Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation
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Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

机译：牛血清白蛋白席夫碱复合物作为人工金属酶，对环境友好的对映选择性硫氧化

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Artificial metalloenzymes (BSA- ML ) have been prepared by non-covalent insertion of transition metal Schiff-base complexes, ML (L = 2-hydroxynaphthalen-1-naphthaldehyde and 3,4-diaminobenzenesulfonic acid; M = Co, Mn, V, Fe, Cr), into bovine serum albumin (BSA) as the host protein and were characterized by UV-visible spectroscopy, ESI-TOF mass spectrometry and molecular docking studies. The catalytic activities of the BSA- ML in the selective oxidation of various prochiral sulfides in aqueous media, using H _(2) O _(2) as oxidant, have been evaluated. During the optimization process, pH and the concentrations of catalyst and oxidant were found to have a remarkable influence on both yield and enantioselectivity. In certain cases, BSA- ML gave satisfactory results in the oxidation of organic sulfides to sulfoxides (up to 100% conversion, 100% chemoselectivity, 96% ee and 500 h ~(?1) turnover frequency).
机译：人造金属酶（BSA- ML）是通过非共价插入过渡金属席夫碱配合物ML（L = 2-羟基萘-1-萘醛和3,4-二氨基苯磺酸; M = Co，Mn，V， Fe，Cr）转化为牛血清白蛋白（BSA）作为宿主蛋白，并通过紫外可见光谱，ESI-TOF质谱和分子对接研究进行了表征。使用H _（2）O _（2）作为氧化剂，评估了BSA-ML在水性介质中各种前手性硫化物的选择性氧化中的催化活性。在优化过程中，发现pH值以及催化剂和氧化剂的浓度对产率和对映选择性均具有显着影响。在某些情况下，BSA-ML在有机硫化物氧化为亚砜方面给出了令人满意的结果（高达100％的转化率，100％的化学选择性，96％ee和500 h〜（？1）转换频率）。

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