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首页> 外文期刊>RSC Advances >Sumalactones A–D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense
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Sumalactones A–D, four new curvularin-type macrolides from a marine deep sea fungus Penicillium Sumatrense

机译：Sumalactones A–D，来自海洋深海真菌 Penicillium Sumatrense 的四种新的屈伏林素型大环内酯类药物

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摘要

Sumalactones A–D (1–4), four new curvularin-type macrolides, together with two known analogues, curvularin (5) and dehydrocurvularin (6), were isolated from Penicillium Sumatrense, a marine fungus isolated from deep-sea sediments. Sumalactones C (3) and D (4) are unprecedented curvularin-type macrolides bearing a rare 11-membered macrolide skeleton. Their structures were elucidated on the basis of intensive spectroscopic analysis. The absolute configurations of compounds 1–4 were determined by CD spectra and modified Mosher's method. Compound 6 showed significant inhibition activity towards LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 value of 0.91 μM.
机译：从野生海生真菌 Penicillium Sumatrense 中分离出了Sumalactones A–D（1-4），四种新的curvularin型大环内酯以及两种已知的类似物curvularin（5）和dehydrocurvularin（6）。来自深海沉积物。 Sumalactones C（3）和D（4）是史无前例的curvularin型大环内酯，带有罕见的11元大环内酯骨架。在深入的光谱分析的基础上阐明了它们的结构。化合物1-4的绝对构型由CD光谱和改良的Mosher方法确定。化合物6对RAW 264.7巨噬细胞中LPS诱导的一氧化氮生成具有明显的抑制活性，IC 50 值为0.91μM。

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