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首页> 外文期刊>RSC Advances >Zein regulating apatite mineralization, degradability, in vitro cells responses and in vivo osteogenesis of 3D-printed scaffold of n-MS/ZN/PCL ternary composite
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Zein regulating apatite mineralization, degradability, in vitro cells responses and in vivo osteogenesis of 3D-printed scaffold of n-MS/ZN/PCL ternary composite

机译：玉米醇溶蛋白调节3D打印n-MS / ZN / PCL三元复合材料支架的磷灰石矿化，降解性，体外细胞反应和体内成骨作用

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Bioactive and degradable scaffolds of nano magnesium silicate (n-MS)/zein (ZN)/poly(caprolactone) (PCL) ternary composites were prepared by 3D-printing method. The results showed that the 3D-printed scaffolds possessed controllable pore structure, and pore morphology, pore size, porosity and pore interconnectivity of the scaffolds can be efficiently adjusted. In addition, the apatite-mineralization ability of the scaffolds in simulated body fluids was obviously improved with the increase of ZN content, in which the scaffold with 20 w% ZN (C20) possessed excellent apatite-mineralization ability. Moreover, the degradability of the scaffolds was significantly enhanced with the increase of ZN content in the scaffolds. The degradation of ZN produced acidic products that could neutralize the alkaline products from the degradation of n-MS, which avoid the increase of pH value in degradable solution. Furthermore, the MC3T3-E1 cells responses ( e.g. proliferation and differentiation, etc. ) to the scaffolds were significantly promoted with the increase of ZN content. The in vivo osteogenesis of the scaffolds implanted the femur defects of rabbits was investigated by micro-CT and histological analysis. The results demonstrated that the new bone formation was significantly enhanced with the increase of ZN content, in which the C20 scaffold induced the highest new bone tissues, indicating excellent osteogenesis. The results suggested that the ZN in the ternary composite scaffolds played key roles in assisting bone regeneration in vivo .
机译：通过3D打印方法制备了纳米硅酸镁（n-MS）/玉米醇溶蛋白（ZN）/聚己内酯（PCL）三元复合材料的生物活性和可降解支架。结果表明3D打印的支架具有可控的孔结构，并且可以有效地调节支架的孔形态，孔径，孔隙率和孔互连性。另外，随着ZN含量的增加，支架在模拟体液中的磷灰石矿化能力明显提高，其中具有20w％ZN（C20）的支架具有优异的磷灰石矿化能力。此外，随着支架中ZN含量的增加，支架的可降解性显着增强。 ZN的降解产生的酸性产物可以中和n-MS降解的碱性产物，从而避免了可降解溶液中pH值的增加。此外，随着ZN含量的增加，MC3T3-E1细胞对支架的反应（例如增殖和分化等）被显着促进。通过显微CT和组织学分析研究了植入股骨缺损的支架的体内成骨作用。结果表明，随着ZN含量的增加，新骨的形成显着增强，其中C20支架诱导了最高的新骨组织，表明成骨性极好。结果表明，三元复合支架中的ZN在协助体内骨再生中起关键作用。

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