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首页> 外文期刊>RSC Advances >Silica gel-immobilized multidisciplinary materials applicable in stereoselective organocatalysis and HPLC separation
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Silica gel-immobilized multidisciplinary materials applicable in stereoselective organocatalysis and HPLC separation

机译：硅胶固定的多学科材料，可用于立体选择性有机催化和HPLC分离

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摘要

In this pilot study, we present novel bifunctional silica gel-immobilized materials applicable as heterogeneous organocatalysts and stationary phases in HPLC. The materials provided high stereoselectivity in both batch and continuous flow catalysis of a model Michael addition (cyclohexanone to (E)-β-nitrostyrene). In the batch reaction, the catalysts proved their sustainable catalytic activity over five consecutive recycling experiments. Under continuous flow reaction conditions, the catalytic activity was found to be superior to the batch reaction, and moreover, the same immobilized materials were utilized as stationary phases in HPLC showing very good chemoselective separation of model acidic analytes.
机译：在这项初步研究中，我们介绍了新型的双功能硅胶固定材料，可用作HPLC中的非均相有机催化剂和固定相。该材料在迈克尔模型加成反应（（（em> E ）-β-硝基苯乙烯）环己酮）的间歇和连续流催化中均具有很高的立体选择性。在间歇反应中，催化剂在五个连续的循环实验中证明了其可持续的催化活性。在连续流动的反应条件下，发现催化活性优于间歇反应，此外，相同的固定化材料在HPLC中用作固定相，显示出对酸性模型分析物的很好的化学选择性分离。

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