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首页> 外文期刊>RSC Advances >Fabrication of a blood compatible composite membrane from chitosan nanoparticles, ethyl cellulose and bacterial cellulose sulfate
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Fabrication of a blood compatible composite membrane from chitosan nanoparticles, ethyl cellulose and bacterial cellulose sulfate

机译：由壳聚糖纳米颗粒，乙基纤维素和细菌纤维素硫酸盐制备血液相容性复合膜

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A heparin-like composite membrane was fabricated through electrospinning chitosan nanoparticles (CN) together with an ethylcellulose (EC) ethanol solution onto a bacterial cellulose sulfate membrane (BCS). Scanning electron microscopy images revealed that there were no chitosan particles in the obtained composite CN-EC/BCS membranes (CEB), indicating CN had been stretched to nanofibers. X-ray photoelectron spectroscopy verified the existence of –NH _(2) from chitosan and –SO _(3) ~(?) from BCS on the surface of CEB membranes. Positively charged CN in the electrospinning solution and negatively charged BCS on the collector increased the electrostatic force and the electrospinning ability of the EC was increased. The membrane was hydrophobic, with a water contact angle higher than 120°. CEB membranes expressed good blood compatibility according to the results of coagulation time and platelet adhesion experiments. No platelets adhered on the surface of the CEB membranes. An inflammatory response was investigated according to activation of the macrophages seeded onto the membranes. Macrophages seeded on CEB membranes are not activated after 24 h incubation.
机译：通过将壳聚糖纳米颗粒（CN）与乙基纤维素（EC）乙醇溶液一起静电纺丝到细菌硫酸纤维素膜（BCS）上，制备出类肝素复合膜。扫描电子显微镜图像显示，所得的CN-EC / BCS复合膜（CEB）中没有壳聚糖颗粒，表明CN已被拉伸成纳米纤维。 X射线光电子能谱证实了壳聚糖中–NH _（2）和BCS中–SO _（3）〜（？）在CEB膜表面上的存在。电纺丝溶液中带正电的CN和集电器上带负电的BCS增强了静电力，增强了EC的电纺能力。该膜是疏水的，水接触角大于120°。根据凝血时间和血小板粘附实验的结果，CEB膜表现出良好的血液相容性。没有血小板粘附在CEB膜的表面上。根据接种在膜上的巨噬细胞的活化来研究炎症反应。孵育24小时后，没有激活接种在CEB膜上的巨噬细胞。

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