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Optimizing the SERS enhancement of a facile gold nanostar immobilized paper-based SERS substrate

机译：优化简便的金纳米星固定纸基SERS基质的SERS增强

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While surface-enhanced Raman scattering (SERS) is a useful technique for the rapid and sensitive detection of biochemical compounds, conventional SERS chips suffer from high cost, complicated fabrication, inefficient sample collection processes and being not biocompatible. Here, we developed a facile, low-cost and highly sensitive gold nanostar (AuNS) immobilized paper-based SERS substrate that can be easily prepared in any laboratory. We performed studies on the paper materials, immobilization strategies, and SERS acquisition conditions to optimize the SERS enhancement and demonstrated that an optimized SERS signal was obtained from a dry substrate and wet analyte configuration suitable for rapid point-of-care detection. Using crystal violet (CV) as the Raman probe molecule, the optimized SERS substrate was prepared by having multiple drops of ～100 pM of sodium citrate-treated colloidal AuNS on common laboratory filter paper before acquiring SERS spectra of CV freshly dripped onto the pre-dried AuNS-filter paper substrate. The optimized AuNS-filter paper substrate exhibited a SERS enhancement factor higher than that of two commercial Au/Ag-based SERS chips, with a detection limit of 1 nM CV and a SERS enhancement factor of up to 1.2 × 107. Such an optimized dry substrate and wet analyte configuration meant that the paper-based SERS substrate could be stored before use and Raman acquisition could be performed immediately without the need for the sample to dry. This makes the AuNS-filter paper substrate a simple and low-cost tool for trace level detection of biochemical species in a rapid, sensitive and non-destructive manner.
机译：尽管表面增强拉曼散射（SERS）是一种快速，灵敏地检测生化化合物的有用技术，但传统的SERS芯片成本高，制造复杂，样品采集过程效率低并且与生物不相容。在这里，我们开发了一种简便，低成本，高灵敏度的金纳米星（AuNS）固定纸基SERS基质，可以在任何实验室中轻松制备。我们对纸质材料，固定化策略和SERS采集条件进行了研究，以优化SERS增强效果，并证明了从适于快速现场检测的干基质和湿分析物配置获得了优化的SERS信号。使用结晶紫（CV）作为拉曼探针分子，通过在普通实验室滤纸上滴加约100 pM柠檬酸钠处理的胶体AuNS，制备新的SERS底物，然后获得新鲜滴落到预分离器上的CV的SERS光谱。干燥的AuNS滤纸基材。经过优化的AuNS滤纸基材表现出的SERS增强因子高于两个基于商业Au / Ag的SERS芯片，检测限为1 nM CV，SERS增强因子高达1.2×10 7 。这种优化的干底物和湿分析物配置意味着可以在使用前存储纸基SERS底物，并且可以立即进行拉曼采集，而无需干燥样品。这使AuNS滤纸基材成为一种简单，低成本的工具，可以快速，灵敏且无损地检测生物化学物质的痕量水平。

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