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首页> 外文期刊>RSC Advances >Hydrolysis of cis- and transplatin: structure and reactivity of the aqua complexes in a solvent free environment
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Hydrolysis of cis- and transplatin: structure and reactivity of the aqua complexes in a solvent free environment

机译：顺铂和反铂水解：无溶剂环境中水配合物的结构和反应性

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摘要

Singly aquated and diaquated species are key intermediates in the mechanism responsible for the antitumor activity of cisplatin. Aqua complexes [PtX(NH3)2(H2O)]+ (X = Cl, OH), obtained in water by hydrolysis of cisplatin and of the inactive isomer transplatin, are transferred into the gas-phase by electrospray ionization. The so-formed ions, cis- and trans-[PtX(NH3)2(H2O)]+, have been allowed to react with selected ligands, representing platination targets in the biological environment. The reaction kinetics monitored in the gas-phase show consistently higher reactivity for the chloro complexes, [PtCl(NH3)2(H2O)]+, with respect to the hydroxo counterparts, [Pt(OH)(NH3)2(H2O)]+. The latter species, both cis- and trans-isomers, have been assayed by IRMPD spectroscopy in the NH/OH stretching region and their vibrational and geometric features are compared with the ones pertaining to the already described chloro complexes, cis- and trans-[PtCl(NH3)2(H2O)]+.
机译：单水和渗水物种是负责顺铂抗肿瘤活性的机制的关键中间体。水族络合物[PtX（NH 3 ） 2 （H 2 O）] + （X = Cl，OH）在水中通过顺铂和非活性异构体跨铂的水解而获得，然后转移到相通过电喷雾电离。如此形成的离子 cis -和 trans -[PtX（NH 3 ） 2 （H 2 O）] + ，已被允许与选定的配体反应，代表生物环境中的电镀目标。在气相中监测的反应动力学显示出对氯配合物[PtCl（NH 3 ） 2 < / small>（H 2 O）] + ，相对于羟基化合物[Pt（OH ）（NH 3 ） 2 （H 2 O）] + 。在NH / OH伸展区中通过IRMPD光谱法测定了后者的 cis -和 trans -异构体，并将它们的振动和几何特征进行了比较。与已经描述的氯配合物 cis -和 trans -[PtCl（NH 3 ） 2 （H 2 O）] + 。

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