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首页> 外文期刊>RSC Advances >Acetylation of BLM protein regulates its function in response to DNA damage
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Acetylation of BLM protein regulates its function in response to DNA damage

机译：BLM蛋白的乙酰化可调节其功能以应对DNA损伤

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Bloom syndrome is an autosomal recessive disease with phenotypes of cancer predisposition and premature aging caused by mutations of the blm gene. BLM belongs to the RecQ DNA helicase family and functions in maintaining genomic stability. In this study, we found that several lysine residues of BLM were acetylated in cells. The dynamic acetylation levels of BLM were regulated by CBP/p300 and SIRT1. We further identified that five lysines, K476, K863, K1010, K1329, and K1411, are the major acetylation sites. Treating cells with different DNA damage agents found that acetylation of BLM was different in response to etoposide and hydroxyurea, suggesting that BLM acetylation may have multiple functions in DNA repair.
机译：布卢姆综合征是一种常染色体隐性遗传疾病，具有由 blm 基因突变引起的癌症易感性和过早衰老的表型。 BLM属于RecQ DNA解旋酶家族，在维持基因组稳定性方面起作用。在这项研究中，我们发现BLM的几个赖氨酸残基在细胞中被乙酰化。 BLM的动态乙酰化水平由CBP / p300和SIRT1调节。我们进一步确定了五个赖氨酸，K476，K863，K1010，K1329和K1411是主要的乙酰化位点。用不同的DNA损伤剂处理细胞后，发现BLM的乙酰化反应对依托泊苷和羟基脲的反应不同，这表明BLM乙酰化在DNA修复中可能具有多种功能。

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