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首页> 外文期刊>RSC Advances >Antibacterial and cytocompatible AgNPs constructed with the assistance of Mefp-1 for orthopaedic implants
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Antibacterial and cytocompatible AgNPs constructed with the assistance of Mefp-1 for orthopaedic implants

机译：借助Mefp-1构建的用于骨科植入物的抗菌和细胞相容性AgNP

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The increasing threat of orthopedic implant failure caused by infection and loosening intensifies the need for novel surface functional treatment. In this study, a thin mussel adhesive protein (Mefp-1)/silver nanoparticle (AgNP) composite film constructed on titania nanotubes (TNTs) via a simple dip-coating method has been demonstrated. The TNT/Mefp-1/AgNP coating exhibits both high antibacterial activity and adequate cytocompatibility. The adherent Mefp-1 film could promote preosteoblast proliferation and reduce AgNP-induced cytotoxicity. The AgNPs (～10 nm) constructed with the assistance of Mefp-1 are effective for the elimination of both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) via a combination of contact-killing and release-killing modes. This facile and mild functionalization strategy exhibits promising applications in surface antibacterial modifications, especially in three-dimensional sophisticated medical devices.
机译：由感染和松动引起的骨科植入物失效的威胁越来越大，因此需要进行新型表面功能治疗。在这项研究中，已经证明了通过简单的浸涂法在二氧化钛纳米管（TNT）上构建的薄贻贝粘附蛋白（Mefp-1）/银纳米颗粒（AgNP）复合膜。 TNT / Mefp-1 / AgNP涂层既显示高抗菌活性又具有足够的细胞相容性。粘附的Mefp-1膜可促进成骨细胞增殖并降低AgNP诱导的细胞毒性。用Mefp-1构建的AgNPs（〜10 nm）可有效消除革兰氏阳性金黄色葡萄球菌（ S。aureus ）和革兰氏阴性大肠杆菌（大肠杆菌）通过结合，具有接触杀伤和释放杀伤两种模式。这种简便而温和的功能化策略在表面抗菌修饰中，特别是在三维复杂医疗设备中，显示出广阔的应用前景。

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