Cost effective surface functionalization of gold nanoparticles with a mixed DNA and PEG monolayer for nanotechnology applications

Risheng Wang; Isabella Bowling; Wenyan Liu

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Cost effective surface functionalization of gold nanoparticles with a mixed DNA and PEG monolayer for nanotechnology applications

机译：具有混合DNA和PEG单层的金纳米颗粒的经济有效的表面功能化，用于纳米技术应用

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A cost effective and generally applicable co-functionalization of gold nanoparticles with a mixed DNA and PEG polymers is reported. Compared to the pure DNA functionalization method, this protocol uses a much smaller amount of thiol-DNA to achieve a similar binding efficacy of gold nanoparticles with DNA origami nanostructures. The lower consumption of DNA provides a scaling-up potential for the application of DNA–nanoparticle conjugates in nanotechnology.

机译：已经报道了具有混合的DNA和PEG聚合物的金纳米颗粒的成本有效且普遍适用的共官能化。与纯DNA功能化方法相比，此协议使用的硫醇DNA量要少得多，以实现具有DNA折纸纳米结构的金纳米颗粒的相似结合效果。较低的DNA消耗为将DNA纳米粒子偶联物应用于纳米技术提供了扩大规模的潜力。

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《RSC Advances》 |2017年第7期|共4页
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Risheng Wang; Isabella Bowling; Wenyan Liu;
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1. Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker [J] . Harrison Emma, Coulter Jonathan A., Dixon Dorian Nanomedicine . 2016,第7期

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2. Tailoring the surface potential of gold nanoparticles with self-assembled monolayers with mixed functional groups [J] . Lin Y.-C., Yu B.-Y., Lin W.-C., Journal of Colloid and Interface Science . 2009,第1期

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3. Cost effective surface functionalization of silver nanoparticles for high yield immobilization of Aspergillus oryzae β-galactosidase and its application in lactose hydrolysis [J] . Shakeel Ahmed Ansari, Rukhsana Satar, Fahad Alam, Process Biochemistry . 2012,第12期

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4. Fabrication of Glucosamine Functionalized Gold/Silver Glyconanoparticles from Nanoclusters for Biomedical Nanotechnology: Multifunctional glyconanoparticles [C] . Murugan Veerapandian, Chang-hyun Jang, Kyusik Yun IEEE Conference on Nanotechnology . 2009

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5. DNA-functionalized gold nanoparticles: Properties and applications in materials assembly, biodiagnostics, and bioimaging. [D] . Xu, Xiaoyang. 2009

机译：DNA功能化的金纳米粒子：在材料组装，生物诊断和生物成像中的特性和应用。
6. Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers [O] . James A. Milton, Samson Patole, Huabing Yin, 2013

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7. Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using -sulfanyl--amino-PEG [O] . Keitaro Yoshimoto, Hoshino Yuki, Ishii Takehiko, 2008

机译：通过使用-硫烷基-氨基-PEG增加功能化的抗原，将抗原功能化的PEG化的金纳米颗粒与抗体固定化的表面的结合增强

Cost effective surface functionalization of gold nanoparticles with a mixed DNA and PEG monolayer for nanotechnology applications

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