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首页> 外文期刊>RSC Advances >Quercetin as a simple but versatile primer in dentin bonding
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Quercetin as a simple but versatile primer in dentin bonding

机译：槲皮素是牙本质粘合中的一种简单但用途广泛的底漆

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Poor bonding stability remains the “Achilles' heel” of dentin bonding, a simple and effective approach to inhibit the activities of both exogenous collagenases and endogenous MMPs, and prevention of the growth of bacterial biofilm is therefore highly demanded. In the present study, a quercetin/ethanol solution was developed as a multifunctional primer to pretreat the dentin surface during adhesive restoration. The results showed that pretreatment with quercetin/ethanol solutions (0.5 and 1.0 wt%) on the dentin surface effectively preserved the bonding strength after one-month of collagenase aging (p < 0.05). Irrespective of aging, lower nanoleakage expression and less cohesive failure in dentin were observed in the quercetin-treated groups (p < 0.05). Compared with the control group, the in situ zymography test revealed that the 0.5 and 1.0 wt% quercetin-treated dentin effectively inhibited MMP activity, while their contact angles significantly increased. Live/dead bacterial staining and the MTT assay demonstrated that the 0.5 and 1.0 wt% quercetin groups exerted significant bactericidal effects while inhibiting biofilm growth of Streptococcus mutans (p < 0.05). We believe that a quercetin/ethanol solution might serve as a simple but versatile primer to provide dentists with a promising approach to obtain desirable bonding stability and to prevent secondary caries, thereby preventing the frequent replacement of resin-based restorations.
机译：不良的粘合稳定性仍然是牙本质粘合的“致命弱点”，这是一种抑制外源胶原酶和内源性MMP活性的简单有效的方法，因此迫切需要防止细菌生物膜生长的方法。在本研究中，槲皮素/乙醇溶液已开发为多功能底漆，可在胶粘剂修复过程中预处理牙本质表面。结果表明，在胶原酶老化一个月后，用槲皮素/乙醇溶液（0.5和1.0 wt％）预处理牙本质表面可有效保留粘合强度（ p <0.05）。不论老化程度如何，在槲皮素治疗组中，牙本质中的纳米泄漏表达较低，而内聚力破坏较少（ p <0.05）。与对照组相比，原位酶谱测试表明，槲皮素处理的0.5和1.0 wt％的牙本质能有效抑制MMP活性，而它们的接触角却显着增加。活/死细菌染色和MTT分析表明0.5和1.0 wt％槲皮素基团在抑制变形链球菌（ p <0.05）的生物膜生长的同时发挥了显着的杀菌作用。我们认为，槲皮素/乙醇溶液可以用作简单但用途广泛的底漆，从而为牙医提供一种有希望的方法，以获得所需的粘合稳定性并防止继发龋齿，从而防止树脂基修复体的频繁更换。

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