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首页> 外文期刊>RSC Advances >Chemical and cellular antioxidant activity of flavone extracts of Labisia pumila before and after in vitro gastrointestinal digestion
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Chemical and cellular antioxidant activity of flavone extracts of Labisia pumila before and after in vitro gastrointestinal digestion

机译：胃肠消化前后黄芪中黄酮提取物的化学和细胞抗氧化活性

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摘要

Two kinds of flavone extracts were extracted and purified from Labisia pumila (LP). High-performance liquid chromatography (HPLC) analysis was used to determinate the flavones in the extracts, and catechin, glycitin, rutin, naringin, and myricetin were identified in the LP leaf extract (LPL-F) while genistin, naringin, and myricetin were found in the stem extract (LPS-F). Specific flavonol compounds mediated the satisfactory scavenging abilities. The flavone leaf extracts performed better than the stem extracts in chemical antioxidative activities but worse in cellular antioxidative capabilities. The chemical and cellular antioxidative activities were not obviously changed by gastrointestinal digestion but slightly changed at the last 2 hours of intestinal digestion because prolonged exposure to alkaline conditions could destroy the structure of flavonoids. Changes in MDA and GSH content, and enzyme activities of SOD and GSH-Px in human erythrocytes during GI digestion indicated the possible intracellular antioxidant-detoxifying mechanisms were through attenuating AAPH-induced oxidative stress by inhibiting ROS generation, in which stem extracts performed the better.
机译：提取和纯化了从拉比西亚普米拉（LP）的两种黄酮提取物。高效液相色谱（HPLC）分析法用于测定提取物中的黄酮，并在LP叶提取物（LPL-F）中鉴定出儿茶素，甘露素，芦丁，柚皮素和杨梅素，而染料木黄酮，柚皮素和杨梅素的含量较高。在茎提取物中发现（LPS-F）。特定的黄酮醇化合物介导令人满意的清除能力。黄酮叶提取物在化学抗氧化活性方面优于茎部提取物，但在细胞抗氧化能力方面较差。胃肠道消化的化学和细胞抗氧化活性没有明显改变，但在肠道消化的最后2小时略有变化，因为长时间暴露于碱性条件下会破坏类黄酮的结构。胃肠道消化过程中人红细胞中MDA和GSH含量的变化以及SOD和GSH-Px的酶活性变化表明，可能的细胞内抗氧化解毒机理是通过抑制ROS的产生来减弱AAPH诱导的氧化应激，其中茎提取物表现更好。 。

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