Novel steroidal saponins with cytotoxic activities from the roots of <em>Ophiopogon japonicus</em> (L. f.) Ker-Gawl

Yan Wu; Su-Xia Bi; Zhen Huang; Jin Qi; Bo-Yang Yu

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Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl

机译：新型麦冬皂甙具有甾体皂苷的功能，该皂苷来自麦冬（L. f。）Ker-Gawl

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摘要

Six new steroidal saponins (1–6) and one known steroidal saponin (7) were obtained from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl. Their structures were determined by the detailed analysis of extensive nuclear magnetic resonance and mass spectroscopic data. The in vitro cytotoxic activities of these compounds against MDA-MB-435, HepG2 and A549 cell lines were also investigated.

机译：从O麦冬（L. f。）Ker-Gawl的根中获得了六种新的甾体皂苷（1-6）和一种已知的甾体皂苷（7）。通过广泛的核磁共振和质谱数据的详细分析确定了它们的结构。还研究了这些化合物对MDA-MB-435，HepG2和A549细胞系的体外细胞毒活性。 展开▼

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《RSC Advances》 |2018年第5期|共8页

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Yan Wu; Su-Xia Bi; Zhen Huang; Jin Qi; Bo-Yang Yu;
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中图分类化学;

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1. Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl [J] . Yan Wu, Su-Xia Bi, Zhen Huang, RSC Advances . 2018,第5期

机译：新型麦冬皂甙具有甾体皂苷的功能，该皂苷来自麦冬（L. f。）Ker-Gawl

2. Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl [J] . Wu Yan, Bi Su-Xia, Huang Zhen, RSC Advances . 2018,第5期

机译：新型甾体皂苷，具有来自Ophiopogon Japonicus（L.F。）Ker-Gawl的根源的细胞毒性活动

3. Correlation among cytotoxicity, hemolytic activity and the composition of steroidal saponins from Paris L. [J] . LiuZ., GaoW., JingS., Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2013,第2期

机译：巴黎L细胞毒性，溶血活性和甾体皂苷组成的相关性

4. Development of species-specific SCAR (sequence-characterized amplified region) markers for identification of famous-region drug Ophiopogon japonicus (L.f.) Ker-Gawl [C] . Zhu Zhen-Hong, Ge U-Jun, Wang Yu IT in Medicine and Education (ITME), 2011 International Symposium on . 2011

机译：开发用于鉴定著名地区药物麦冬（L.f.）Ker-Gawl的物种特异性SCAR（序列表征扩增区）标记

5. Synthesis and cytotoxic activity of diosgenyl saponin analogues. [D] . Kaskiw, Matthew. 2009

机译：薯os皂苷类似物的合成和细胞毒活性。

6. Effects of steroidal saponins extract from Ophiopogon japonicus root ameliorates doxorubicin-induced chronic heart failure by inhibiting oxidative stress and inflammatory response [O] . Zhongwei Wu, Xuekai Zhao, Akira Miyamoto, 2019

机译：麦冬根中甾体皂苷提取物通过抑制氧化应激和炎症反应改善阿霉素诱发的慢性心力衰竭

7. Isolation, chemical characterization and biological activity of red clover (Trifolium pratense L.) root saponins [O] . Wiesław Oleszek, Marian Jurzysta 2014

机译：红三叶草（Trifolium pratense L.）根皂苷的分离，化学表征和生物活性

1. HPLC法同时测定麦冬药材中麦冬皂苷Ra和慈溪麦冬皂苷A的含量 [J] . 胥秀英 ,郑一敏 ,傅善权 . 中国药房 . 2010,第039期

2. 建立UPLC-MS/MS方法测定麦冬皂苷D和麦冬皂苷D'及临床风险评估 [J] . 姚泓 ,王宇光 ,高月 . 中文科技资料目录-中草药 . 2019,第006期

3. 麦冬皂苷研究Ⅶ·麦冬皂苷肠溶微球的释放度研究 [J] . 沈岚 ,冯怡 ,徐德生 . 中成药 . 2006,第002期

4. 基于甾体皂苷的襄麦冬块根抑制性差减杂交文库的构建 [J] . 余海忠 ,王海燕 ,赵慧君 . 西南农业学报 . 2018,第002期

5. 襄麦冬总甾体皂苷提取工艺优化及体外清除自由基活性评价 [J] . 杨佳娣 ,柯婉 ,叶国栋 . 食品与机械 . 2018,第004期

6. 麦冬皂苷研究Ⅲ·麦冬须根中麦冬总皂苷和麦冬皂苷D、D＇的含量测定方法研究 [C] . 徐德生 ,吴笑如 ,冯怡 . 中国药学会学术年会 . 2004

7. 川麦冬中甾体皂苷类成分的研究 [A] . 刘奕训 . 2013

1. 一种麦冬皂苷D与麦冬皂苷D’组成的制剂及其降血糖药物新用途 [P] . 中国专利： CN110664827A . 2020-01-10

2. 一种麦冬皂苷D与麦冬皂苷D’组成的制剂及其降血脂药物新用途 [P] . 中国专利： CN110652519A . 2020-01-07

3. Cosmetic composition containing Scutellaria baicalensis extract and Ophiopogon Japonicus root extract and Plantago AsLatica Seed extract [P] . 外国专利： KR101978145B1 . 2019-05-15

机译：含有黄S提取物，麦冬根提取物和车前草种子提取物的化妆品组合物

4. COSMETIC COMPOSITION CONTAINING SCUTELLARIA BAICALENSIS EXTRACT AND OPHIOPOGON JAPONICUS ROOT EXTRACT AND PLANTAGO ASLATICA SEED EXTRACT [P] . 外国专利： KR20130058106A . 2013-06-04

机译：含有黄UT提取物和日本蛤子根提取物及浮游植物芦荟种子提取物的化妆品成分

5. Process for the preparation of fermentation product of esculent roots using microorganism having fermentation activity of saponin-containing esculent roots [P] . 外国专利： KR100919070B1 . 2009-09-28

机译：利用具有含皂苷的食根的发酵活性的微生物制备食根的发酵产物的方法

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Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl

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