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首页> 外文期刊>RSC Advances >Dual-response CuS@MnO2 nanoparticles with activatable CT/MR-enhanced in vivo imaging guided photothermal therapy
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Dual-response CuS@MnO2 nanoparticles with activatable CT/MR-enhanced in vivo imaging guided photothermal therapy

机译：可激活的CT / MR增强体内成像引导光热疗法的双反应CuS @ MnO2纳米粒子

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Although photothermal therapy (PTT) has been extensively applied in the treatment of cancer using various types of nanomaterials, low penetration of excitation light, low nanoparticle concentration enrichment and abominable nanoparticle permeation still remain huge obstacles in cancer therapy. Herein, we synthesized stable cupric sulfide nanoparticles (CuS NPs) with small size, which after functionalization with a MnO _(2) coating, were employed for diagnosing and treating tumors. After reacting with an RGD peptide, the nanoparticles were able to target and focus on tumor sites. Once the nanoparticles were enriched in tumors by RGD targeting, the MnO _(2) coating decomposed to Mn ~(2+) ions in the tumor microenvironment. Meanwhile, the decomposition of MnO _(2) allowed the dispersion of aggregated CuS NPs to enter deep tumors, and a 1064 nm laser with powerful penetration was utilized to activate CuS NPs in deep tumors for PTT. More importantly, the generated Mn ~(2+) ions were used for stimuli-enhanced T _(1) -weighted magnetic resonance imaging (T _(1) -MRI) and agminated CuS NPs in tumors were accepted for computed tomography (CT) imaging. It was found that these nanocomposites can accurately indicate tumor sites after being intravenously injected, and in vitro and in vivo experiments illustrated the tremendous potential of these nanoplatforms for use in imaging-guided PTT against HepG2 tumors.
机译：尽管光热疗法（PTT）已被广泛用于使用各种类型的纳米材料治疗癌症，但是激发光的低穿透性，低的纳米粒子浓度富集和可恶的纳米粒子渗透仍然是癌症疗法中的巨大障碍。在这里，我们合成了稳定的小尺寸的硫化铜纳米颗粒（CuS NPs），将其用MnO _（2）涂层功能化后，用于诊断和治疗肿瘤。与RGD肽反应后，纳米颗粒能够靶向并聚焦在肿瘤部位。一旦纳米颗粒通过RGD靶向富集在肿瘤中，MnO_（2）涂层在肿瘤微环境中分解为Mn〜（2+）离子。同时，MnO_（2）的分解使聚集的CuS NPs分散体进入深部肿瘤，并利用具有强大穿透力的1064 nm激光激活深部肿瘤中的CuS NPs用于PTT。更重要的是，将产生的Mn〜（2+）离子用于刺激增强的T _（1）加权磁共振成像（T _（1）-MRI），并将肿瘤中的融合CuS NP用于计算机断层扫描（CT ）成像。已经发现这些纳米复合材料在静脉注射后可以准确地指示肿瘤部位，并且体外和体内实验说明了这些纳米平台在用于成像引导的针对HepG2肿瘤的PTT中的巨大潜力。

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