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3D printed fittings and fluidic modules for customizable droplet generators

机译：3D打印配件和流体模块，用于可定制的液滴发生器

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We developed a rapid and simple method to fabricate microfluidic non-planar axisymmetric droplet generators using 3D printed fittings and commercially available components. 3D printing allows facile fabrication of microchannels albeit with limitations in the repeatability at low resolutions. In this work, we used 3D printed fitting to arrange the flow in the axisymmetric configuration, while the commercially available needles formed a flow-focusing nozzle as small as 60 μm in diameter. We assembled 3D printed fitting, needle, and soft tubes as different modules to make a single droplet generator. The design of our device allowed for reconfiguration of the modules after fabrication to achieve customized generation of droplets. We produced droplets of varying diameters by switching the standard needles and the minimum diameter of droplet obtained was 332 ± 10 μm for 34 G (ID = 60 μm). Our method allowed for generating complex emulsions ( i.e. double emulsions and compartmented emulsions) by adding 3D printed sub-units with the fluidic connections. Our approach offered characteristics complementary to existing methods to fabricate flow-focusing generators. The standardized needles serving as a module offered well-defined dimensions of the channels not attainable in desktop 3D printers, while the 3D printed components, in turn, offered a facile route to reconfigure and extend the flow pattern in the device. Fabrication can be completed in a plug-and-play manner. Overall, the technology we developed here will provide a standard approachable route to generate customized microfluidic emulsions for specific applications in chemical and biological sciences.
机译：我们开发了一种快速简单的方法，可使用3D打印配件和市售组件来制造微流体非平面轴对称液滴发生器。 3D打印允许轻松制造微通道，尽管在低分辨率下的可重复性受到限制。在这项工作中，我们使用3D打印配件将流体布置成轴对称配置，而市售的针头形成了直径小于60μm的流体聚焦喷嘴。我们将3D打印的配件，针头和软管作为不同的模块组装在一起，从而制造出一个液滴发生器。我们设备的设计允许在制造后重新配置模块，以实现定制的液滴生成。我们通过切换标准针头产生了不同直径的液滴，对于34 G（ID = 60μm），获得的最小液滴直径为332±10μm。我们的方法允许通过添加具有流体连接的3D打印子单元来生成复杂的乳液（即双重乳液和间隔乳液）。我们的方法提供了与现有制造流聚焦发生器的方法互补的特性。用作模块的标准化针提供了台式3D打印机无法达到的清晰定义的通道尺寸，而3D打印的组件又提供了一种方便的途径来重新配置和扩展设备中的流型。制造可以即插即用的方式完成。总体而言，我们在这里开发的技术将提供一条标准的可行途径，以生成用于化学和生物科学特定应用的定制微流体乳液。

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