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Synthesis of fluorescent drug molecules for competitive binding assay based on molecularly imprinted polymers

机译：基于分子印迹聚合物合成用于竞争结合测定的荧光药物分子

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Fluorescent immunosorbent assay (FIA) is very promising for sensitive and selective analysis in bio-medical applications. Here, we proposed an assay, using fluorescent engineering of analytes and the corresponding molecularly imprinted polymers (MIPs) as a plastic antibody. Three drug molecules (metronidazole, zidovudine and lamivudine) were condensed with 9-aminoacridine, using succinic anhydride as a spacer. The target products were characterized with ~(1) H-NMR, IR and mass spectrometry. UV-vis absorption and fluorescent properties of the fluorophore-labeled drug molecules were investigated. Feasibility of the fluorescent biomimetic immunosorbent assay based on MIPs was demonstrated in the solution. This work will provide sound foundation for the future application in real sample.
机译：荧光免疫吸附测定（FIA）对于生物医学应用中的敏感和选择性分析非常有前途。在这里，我们提出了一种分析方法，利用分析物的荧光工程技术和相应的分子印迹聚合物（MIP）作为塑料抗体。使用琥珀酸酐作为间隔基，将三个药物分子（甲硝唑，齐多夫定和拉米夫定）与9-氨基ac啶缩合。用〜（1）1 H-NMR，IR和质谱表征目标产物。研究了荧光团标记的药物分子的紫外可见吸收和荧光性质。在溶液中证明了基于MIP的荧光仿生免疫吸附测定的可行性。这项工作将为将来在实际样本中的应用提供良好的基础。

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