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Two decades of antifilarial drug discovery: a review

机译：抗丝虫药物发现的二十年：回顾

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Filariasis is one of the oldest, most debilitating, disabling, and disfiguring neglected tropical diseases with various clinical manifestations and a low rate of mortality, but has a high morbidity rate, which results in social stigma. According to the WHO estimation, about 120 million people from 81 countries are infected at present and an estimated 1.34 billion people live in areas endemic to filariasis and are at risk of infection. In this review, we focus on Lymphatic Filariasis (LF) and provide brief insights on some other filarial conditions. Current drug treatments have beneficial effects in the elimination of only the larval stage of the worms. Very few drugs are available for treatment of filariasis but their repetitive use may give rise to drug resistance. They are also found to be fairly ineffective towards eliminating adult worms. Moreover, no effective vaccine is available for treatment of filariasis. Because of these limitations, development of new antifilarials has been of utmost importance, a fact which encourages researchers to discover new drugs having antifilarial activity. Herein we extensively review developments in the field of antifilarials including the types of filariasis, their historical perspectives, eradication programs, different classes of drug (i.e. synthetic as well as natural), explored product-derived different targets, patents and clinical trials.
机译：丝虫病是最古老，最使人衰弱，致残和毁容的被忽视的热带病之一，具有各种临床表现和低死亡率，但发病率高，导致社会受到污名化。根据世界卫生组织的估计，目前有来自81个国家的约1.2亿人被感染，估计有13.4亿人生活在丝虫病流行地区，有感染的危险。在这篇综述中，我们重点介绍淋巴丝虫病（LF），并就其他一些丝虫病状况提供了简要的见解。当前的药物治疗在仅消除蠕虫的幼虫阶段中具有有益的作用。很少有药物可用于治疗丝虫病，但是重复使用它们可能会引起耐药性。还发现它们在消除成虫方面相当无效。而且，没有有效的疫苗可用于治疗丝虫病。由于这些局限性，开发新的抗丝虫剂至关重要，这一事实鼓励研究人员发现具有抗丝虫活性的新药物。在此，我们广泛回顾了抗丝虫病领域的发展，包括丝虫病的类型，其历史观点，根除计划，不同种类的药物（ ie 合成的和天然的），探索的源自产品的不同目标，专利和临床试验。

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