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首页> 外文期刊>RSC Advances >Pharmacokinetics study of isorhamnetin in rat plasma by a sensitive electrochemical sensor based on reduced graphene oxide
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Pharmacokinetics study of isorhamnetin in rat plasma by a sensitive electrochemical sensor based on reduced graphene oxide

机译：基于还原氧化石墨烯的灵敏电化学传感器在大鼠血浆中异鼠李素的药代动力学研究

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Isorhamnetin (ISO), a flavonol aglycone, plays an important role in human health, such as cardiovascular protection, anti-allergy activity, anti-inflammatory effects, and anticancer activity. Thus, the highly sensitive and rapid detection of ISO, and its pharmacokinetic study, has important clinical significance in the field of medicine. Herein, a simple, rapid, sensitive, and accurate method for the electrochemical determination of isorhamnetin (ISO) for pharmaceutical quality control and pharmacokinetic research was developed using an electrochemically reduced graphene oxide modified glassy carbon electrode (ERGO/GCE). The results indicated that the ERGO/GCE remarkably increased the peak currents of ISO oxidation. Under optimized conditions, using differential pulse voltammetry (DPV), the peak current had a linear dependence on the concentration of ISO in the range of 1.0 × 10?8 to 1.2 × 10?5 M with a low detection limit of 3.2 × 10?9 M. The present voltammetric method has been successfully applied to the detection of ISO in tablets and in plasma. Moreover, this assay has also been successfully applied in the pharmacokinetic study of ISO in vivo through intragastric administration of tablets to SD-rats. Therefore, this strategy opens up a new avenue for the application of an electrochemical method in the field of ISO pharmacokinetics.
机译：黄酮醇苷元异鼠李素（ISO）在人类健康中发挥重要作用，如心血管保护，抗过敏活性，抗炎作用和抗癌活性。因此，ISO的高灵敏度和快速检测及其药代动力学研究在医学领域具有重要的临床意义。在此，使用电化学还原的氧化石墨烯修饰的玻碳电极（ERGO / GCE），开发了一种简单，快速，灵敏，准确的电化学方法测定异鼠李素（ISO），以进行药物质量控制和药代动力学研究。结果表明，ERGO / GCE显着提高了ISO氧化的峰值电流。在优化条件下，使用差分脉冲伏安法（DPV），峰值电流与ISO浓度呈线性关系，范围为1.0×10 ？8 10 ？5 M，检测限低至3.2×10 ？9 M。目前的伏安法具有已成功应用于片剂和血浆中ISO的检测。此外，该测定法还通过对SD大鼠进行胃内给药将其成功地应用于ISO体内药代动力学研究。因此，该策略为电化学方法在ISO药代动力学领域的应用开辟了一条新途径。

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