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首页> 外文期刊>RSC Advances >Dual-generation dendritic mesoporous silica nanoparticles for co-delivery and kinetically sequential drug release
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Dual-generation dendritic mesoporous silica nanoparticles for co-delivery and kinetically sequential drug release

机译：双代树突状介孔二氧化硅纳米颗粒，用于共递送和动力学顺序药物释放

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Although multi-drug synergetic therapy is increasingly important in clinical application, sophisticated delivery systems with the ability to deliver multiple drugs and realize sequential release with independently tunable kinetics at different stages are highly desirable. In this study, a dual-generation mesoporous silica nanoparticle (DAMSN) with three-dimensional dendrimer-like structure as an adaptable dual drug delivery system is developed. The DAMSN was synthesized via a heterogeneous interfacial reaction and was of uniformly spherical morphology (150–170 nm) with dendritic structures and hierarchical pores (inner pore, 3.5 nm; outer pore, 8.3 nm). And the inner generation of DAMSN was modified with 3-aminopropyltriethoxysilane (APTMS). The IBU and BSA as model drugs were loaded into the inner generation via covalent conjugation and the outer generation by electrostatic adsorption, respectively. Intriguingly, DAMSN underwent a rapid bio-degradation for about 4 days, partly due to its center-radial dendritic channel structure. The release results showed that IBU was of a typical two-phase release profile with almost zero release in the first 12 h and more sustained release for the following 88 h, while BSA was sustained over a long period of 100 h. Notably, the release behaviors of both drugs can be independently tailored by changing the intrinsic properties of the DAMSN. In addition, DAMSN exhibited good bio-compatibility. These results indicated that the dual-generation, dendrimer-like MSN structure could spatiotemporally present different drugs to realize sequential drug release, and has potential use in the field of tissue engineering and regenerative medicine.
机译：尽管多药协同疗法在临床应用中变得越来越重要，但是非常需要能够在不同阶段输送多种药物并实现具有独立可调动力学的顺序释放的先进输送系统。在这项研究中，开发了具有三维树枝状大分子结构的双代介孔二氧化硅纳米颗粒（DAMSN），作为一种适应性的双药物递送系统。 DAMSN是通过异质界面反应合成的，具有均匀的球形形态（150-170 nm），具有树枝状结构和分层孔（内部孔3.5 nm;外部孔8.3 nm）。 DAMSN的内部生成被3-氨丙基三乙氧基硅烷（APTMS）修饰。作为模型药物的IBU和BSA分别通过共价结合进入内生代，并通过静电吸附进入外生代。有趣的是，DAMSN经历了大约4天的快速生物降解，部分原因是其中心-放射状的树突状通道结构。释放结果表明，IBU具有典型的两阶段释放特性，在开始的12小时内释放几乎为零，在随后的88小时内释放更持久，而BSA则持续了100小时。值得注意的是，可以通过改变DAMSN的内在特性来独立调整两种药物的释放行为。另外，DAMSN表现出良好的生物相容性。这些结果表明，双代树状大分子MSN结构可以在时空上呈现不同的药物以实现顺序的药物释放，并且在组织工程和再生医学领域具有潜在的用途。

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