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Theranostic nanocomposite from upconversion luminescent nanoparticles and black phosphorus nanosheets

机译：由上转换发光纳米颗粒和黑磷纳米片制成的治疗性纳米复合材料

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An anti-cancer campaign might not be easily achieved through a single therapeutic modality. Collaboration of multimodal therapies and diagnosis could be vital to win the battle against cancer. In this context, we synthesized a multifunctional theranostic nanocomposite (UCNP–BPNS) from upconversion nanoparticles (UCNP) and black phosphorus nanosheets (BPNS) for synergistic photothermal/photodynamic therapies in vitro and dual modal imaging. Core–shell UCNP (NaYF _(4) :Yb,Er@NaGdF _(4) ) and BPNS were synthesized using solvo-thermal and liquid exfoliation methods, respectively, and then covalently conjugated after UCNP was modified with polyacrylic acid and BPNS with methoxypolyethylene glycol amine. The experimental results validate that the nanocomposite exhibited a good photothermal therapy (PTT) effect under 808 nm laser irradiation, endorsing the apparent heat conversion effect of BPNS. Besides, a very good photodynamic therapy (PDT) effect was achieved under 980 nm laser irradiation of the nanocomposite due to F?rster resonance energy transfer from UCNP to BPNS that generated singlet oxygen ( ~(1) O _(2) ). The synergistic PTT/PDT therapeutic effect provided by UCNP–BPNS under simultaneous 808 and 980 nm laser irradiation was significantly higher than either PTT or PDT alone. Furthermore, due to the merit of the outer shell coated on the surface of the core of UCNP, the nanocomposite exhibited good potential for magnetic resonance and upconversion luminescence imaging. These results demonstrated that our multifunctional nanocomposite has promising theranostic efficacy under near infrared laser irradiation.
机译：通过单一的治疗方式可能很难实现抗癌运动。多模式疗法和诊断的合作对于赢得抗癌斗争至关重要。在这种情况下，我们从上转换纳米颗粒（UCNP）和黑磷纳米片（BPNS）合成了多功能的人造纤维纳米复合材料（UCNP-BPNS），用于体外和双模式成像的协同光热/光动力疗法。分别使用溶剂热剥离法和液体剥离法分别合成核-壳UCNP（NaYF _（4）：Yb，Er @ NaGdF _（4））和BPNS，然后将UCNP用聚丙烯酸酯和BPNS改性后共价缀合。甲氧基聚乙二醇胺。实验结果验证了该纳米复合材料在808 nm激光辐照下表现出良好的光热疗法（PTT）效果，证明了BPNS的表观热转换效果。此外，由于从UCNP向BPNS的共振共振能量转移产生了单线态氧（〜（1）O _（2）），纳米复合材料在980 nm激光照射下获得了很好的光动力疗法（PDT）效果。在同时808和980 nm激光照射下，UCNP–BPNS提供的协同PTT / PDT治疗效果显着高于单独的PTT或PDT。此外，由于涂覆在UCNP核表面上的外壳的优点，纳米复合材料表现出良好的磁共振和上转换发光成像的潜力。这些结果表明，我们的多功能纳米复合材料在近红外激光辐照下具有良好的治疗功效。

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