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首页> 外文期刊>RSC Advances >A label-free detection of diethylstilbestrol based on molecularly imprinted polymer-coated upconversion nanoparticles obtained by surface grafting
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A label-free detection of diethylstilbestrol based on molecularly imprinted polymer-coated upconversion nanoparticles obtained by surface grafting

机译：基于表面接枝获得的分子印迹聚合物包覆的上转换纳米粒子的无标记检测己烯雌酚

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Herein, we report a novel fluorescent sensor based on molecularly imprinted polymer-coated upconversion nanoparticles (MIP-coated UCNPs) for the recognition and detection of diethylstilbestrol (DES). We used one-step process to modify the surface of the UCNPs with alkenyl groups, which was not only a simple process, but also greatly saved the preparation time. Then, a molecularly imprinted polymer was synthesized on the UCNPs by the surface-graft molecular imprinting method. MIP-coated UCNPs combine the advantages of UCNPs and molecularly imprinted polymers such as strong fluorescence properties, excellent stability, reusability, good adsorption capacity, and high specificity. After the removal of the template molecules, the UCNPs were able to selectively recognize DES, and the fluorescence intensity decreased as the concentration of DES increased. A good linear relationship was obtained in the concentration range of 50–1000 ng mL?1 with the correlation coefficient of 0.9989, and the detection limit was 12.8 ng mL?1 (S/N = 3). MIP-coated UCNPs could be applied for the detection of DES in real milk samples, and the average recoveries for five different concentrations ranged from 90.3% to 107.8%, with the relative standard deviations (RSD) below 2.7%. This fluorescence sensor provides a more convenient, simple and highly specific method for the on-field detection of DES and is promising for a wide range of applications in the future.
机译：在这里，我们报告基于分子印迹聚合物涂层的上转换纳米粒子（MIP涂层的UCNPs）的新型荧光传感器，用于识别和检测己烯雌酚（DES）。我们使用一步法用烯基修饰UCNPs的表面，这不仅是一个简单的过程，而且大大节省了制备时间。然后，通过表面接枝分子印迹法在UCNPs上合成分子印迹聚合物。涂有MIP的UCNP结合了UCNP和分子印迹聚合物的优点，例如强荧光特性，出色的稳定性，可重复使用性，良好的吸附能力和高特异性。除去模板分子后，UCNPs能够选择性识别DES，并且荧光强度随DES浓度的增加而降低。在浓度范围为50–1000 ng mL ？1 时，具有良好的线性关系，相关系数为0.9989，检出限为12.8 ng mL ？1 （S / N = 3）。涂有MIP的UCNP可用于检测真乳样品中的DES，五个不同浓度的平均回收率在90.3％至107.8％之间，相对标准偏差（RSD）低于2.7％。这种荧光传感器为DES的现场检测提供了一种更方便，简单且高度特定的方法，并有望在将来广泛应用。

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