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首页> 外文期刊>RSC Advances >Paclitaxel-loaded pluronic F127/P123 silica nanocapsules with surface conjugated rhTRAIL for targeted cancer therapy
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Paclitaxel-loaded pluronic F127/P123 silica nanocapsules with surface conjugated rhTRAIL for targeted cancer therapy

机译：载有表面共轭rhTRAIL的紫杉醇载Puronic F127 / P123二氧化硅纳米胶囊用于靶向癌症治疗

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A novel anticancer drug PFPSNT, paclitaxel (PTX)-loaded polymeric F127/P123 silica nanocapsules conjugated with TRAIL (tumor necrosis factor (TNF)-related apoptosis-inducing ligand), was designed and synthesized. Transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-vis absorption and particle size analysis revealed that the synthesized PFPSNT was a spherical particle with a size of 24 nm and excellent colloidal stability. Drug loading efficiency (DL%) and encapsulation ratio (ER%) were 0.39% and 26.5%, and its cumulative release profile was linear. In vitro study showed that PFPSNT had marked cytotoxic and apoptotic activities towards HepG2 (liver cancer cell line) and CaSki (cervical cell line) cells with the IC50 values of 921.07 ng mL?1 and 236.24 ng mL?1, respectively. The antitumor efficacy of PFPSNT was evaluated by using a HepG2-xenografted BALB/c nu/nu mice model. In vivo study showed PFPSNT markedly inhibited HepG2 hepatocellular carcinoma, and its antitumor efficacy was more superior than those of TRAIL, PTX or PTX/F127/P123 silica nanocapsules. Our studies provided a novel strategy to synthesize anticancer nanodrugs with mutiple functions, and demonstrated that PFPSNT was a very effective anticancer drug. This novel nanodrug should be a promising drug for targeted cancer therapy to treat complex cancers.
机译：设计并合成了一种新型的抗癌药物PFPSNT，紫杉醇（PTX）负载的聚合物F127 / P123二氧化硅纳米胶囊与TRAIL（与肿瘤坏死因子（TNF）相关的凋亡诱导配体）偶联。透射电镜（TEM），动态光散射（DLS），紫外可见吸收和粒度分析表明，所合成的PFPSNT为球形颗粒，粒径为24 nm，具有良好的胶体稳定性。载药率（DL％）和包封率（ER％）分别为0.39％和26.5％，其累积释放曲线为线性。 体外研究表明，PFPSNT对具有IC 50 值分别为921.07 ng mL ？1 和236.24 ng mL ？1 。通过使用HepG2-异种移植的BALB / c nu / nu 小鼠模型评估PFPSNT的抗肿瘤功效。 体内研究表明，PFPSNT显着抑制HepG2肝细胞癌，其抗肿瘤作用优于TRAIL，PTX或PTX / F127 / P123二氧化硅纳米胶囊。我们的研究提供了一种具有多种功能的合成抗癌纳米药物的新策略，并证明PFPSNT是一种非常有效的抗癌药物。这种新型的纳米药物应该是用于靶向癌症治疗复杂癌症的有前途的药物。

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