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A nano-magnetic electrochemical sensor for the determination of mood disorder related substances

机译：用于确定情绪障碍相关物质的纳米磁性电化学传感器

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摘要

The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe _(3) O _(4) nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L ~(?1) , respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17β-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples.
机译：通过使用新颖的纳米磁性电化学传感器设计成功实现了与情绪障碍相关物质（如阿米替林，褪黑素和色氨酸）的同时电化学检测，该传感器设计包括用碳量子点修饰的Fe _（3）O _（4）纳米粒子（ MagNP / Cdots）。使用HR-TEM显微镜，XRD和拉曼光谱对磁性复合材料进行表征，并使用微型钕磁体将其施加到玻璃碳电极上。阿米替林，褪黑激素和色氨酸的测定是通过监测pH值为3.0的BR缓冲液中MagNPs / Cdots促进的氧化而进行的，氧化根据明确的差分脉冲伏安峰进行，检出限为5.9、4.4和4.2 nmol L〜 （？1）。尿酸，抗坏血酸，多巴胺，雌三醇和17β-雌二醇等生物干扰物未见明显干扰。磁性混合材料在溶液中高度稳定，为开发低成本和实用的电化学传感器提供了令人兴奋的机遇，这些传感器可用于确定实际临床样品中与情绪障碍相关的物质。

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