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首页> 外文期刊>RSC Advances >The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds via structural and functional optimization using collagen networks
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The enhanced osteogenesis and osteointegration of 3-DP PCL scaffolds via structural and functional optimization using collagen networks

机译：通过使用胶原蛋白网络进行结构和功能优化，增强了3-DP PCL支架的成骨作用和骨整合能力

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Optimal balance between biological activity and mechanical stability should be meticulously considered during scaffold design for bone tissue engineering applications. To fabricate an individualized construct with biomechanical and biological functionality for bone tissue regeneration, a polycaprolactone–collagen (PCL–COL) composite construct was developed through the combination of three-dimensional printing (3-DP) technology and biomimetic collagen matrix incorporation, with a 3-DP PCL framework maintaining the mechanical stability and a porous collagen matrix improving the biological activity. The results indicate that the compressive modulus of the composite constructs increased synergistically (over 40 MPa), providing sufficient mechanical support during new bone formation. On the other hand, the collagen matrix with a micro-porous architecture structurally increased scaffold areas and provided cellular adhesion sites, allowing for the functional construction of a favorable 3D microenvironment for BMSC adhesion, proliferation and extracellular matrix production. Moreover, critical-sized long bone defect (CSD) implantation demonstrated that the optimized composite constructs could promote bone tissue regeneration (5.5-fold) and bone-material osteointegration (4.7-fold), and decrease fibrosis encapsulation, compared to pristine PCL. The results indicate that these biomimetically ornamented PCL–COL constructs exhibit favorable mechanical properties and biological functionality, demonstrating great potential as an effective bone graft substitute for bone defect treatment. Meanwhile, they can also harness the advantages of 3-DP technology and a collagen-based functionalized strategy, facilitating the creation of customized and functional PCL–COL constructs for clinical translation.
机译：在骨组织工程应用的支架设计过程中，应认真考虑生物活性和机械稳定性之间的最佳平衡。为了制造具有生物力学和生物功能的骨构造再生的个性化构建体，通过结合三维打印（3-DP）技术和仿生胶原基质掺入，并结合了聚己内酯-胶原蛋白（PCL-COL）复合构建体， 3-DP PCL框架保持机械稳定性，多孔胶原蛋白基质改善生物活性。结果表明，复合结构的压缩模量协同增加（超过40 MPa），在新骨形成过程中提供了足够的机械支撑。另一方面，具有微孔结构的胶原蛋白基质在结构上增加了支架面积并提供了细胞粘附位点，从而为BMSC粘附，增殖和细胞外基质生产提供了有利的3D微环境的功能性构建。此外，与原始PCL相比，临界尺寸的长骨缺损（CSD）植入表明，优化的复合材料构造物可以促进骨组织再生（5.5倍）和骨材料骨整合（4.7倍），并减少纤维化的包裹。结果表明，这些仿生装饰的PCL–COL构造物具有良好的机械性能和生物学功能，显示出作为治疗骨缺损的有效骨移植替代物的巨大潜力。同时，他们还可以利用3-DP技术的优势和基于胶原蛋白的功能化策略，从而为临床翻译创建定制的功能性PCL–COL构建体提供了便利。

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