• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Enhanced osteogenic activity of Ti alloy implants by modulating strontium configuration in their surface oxide layers
【24h】

Enhanced osteogenic activity of Ti alloy implants by modulating strontium configuration in their surface oxide layers

机译：通过调节表面氧化物层中的锶构型增强Ti合金植入物的成骨活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To guarantee the long-term stability of an orthopaedic implant, non-degradable surface coatings with the ability to selectively release bioactive drugs or ions are especially desirable. In this study, SrO–TiO2 composite coatings were deposited on the surface of Ti alloys, whose release behavior of bioactive Sr ions was modulated by the Sr configurations, either interstitial atoms in solid solution (TiySr2?2yO2) or strontium titanate (SrTiO3). A perfect linear relationship between the amount of the released Sr ions and the Sr content in the coating was observed. Among the SrO-doped TiO2 coatings, the 20% SrO–TiO2 coating where Sr existed in both forms of TiySr2?2yO2 and SrTiO3 not only promoted proliferation of bone cells but also enhanced their osteogenic differentiation, which was proved to be related to its Sr release behavior. However, overdosing with 30% SrO only resulted in one single Sr configuration (SrTiO3) and an inferior osteogenic function. This study suggests that Sr configurations of both interstitial atoms of the solid solution and SrTiO3 can realize the selective release of Sr, but they possibly have different effects on the biological functions and other properties including corrosion resistance.
机译：为了保证骨科植入物的长期稳定性，特别需要具有选择性释放生物活性药物或离子的能力的不可降解的表面涂层。在这项研究中，SrO–TiO 2 复合涂层沉积在Ti合金表面，其生物活性Sr离子的释放行为受Sr构型（间隙原子）的调节固溶体（Ti y Sr 2？2 y < / small> O 2 ）或钛酸锶（SrTiO 3 ）。观察到释放的Sr离子量与涂层中Sr含量之间存在完美的线性关系。在掺有SrO的TiO 2 涂层中，两种都存在Sr的20％SrO–TiO 2 涂层 y Sr 2？2 y 的形式> O 2 和SrTiO 3 不仅促进了骨细胞的增殖，而且增强了其成骨分化，这是被证明与其Sr释放行为有关。然而，过量添加30％SrO仅会导致一种单一Sr构型（SrTiO 3 ）和较差的成骨功能。这项研究表明固溶体的两个间隙原子和SrTiO 3 的Sr构型都可以实现Sr的选择性释放，但是它们可能对生物学功能和其他性能包括耐腐蚀性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号