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首页> 外文期刊>RSC Advances >Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model
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Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model

机译：桃金娘叶提取物绿色合成安全的零价铁纳米颗粒，作为减轻铁负荷过重小鼠（地中海贫血模型）中过量铁的有效剂

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Green synthesis of Myrtus communis -Zero Valent Iron Nanoparticles (MC-ZVINs) was carried out in an alkaline environment. These nanoparticles were introduced for testing in vivo iron chelation in an iron-overload thalassemia model in mice. The MC-ZVINs were characterized by the use of imaging (electron microscopy) and spectroscopic (UV-vis and infrared absorption, dynamic light scattering and X-ray diffraction) methods. These methods demonstrated that some polyphenols are bound to the surfaces of the MC-ZVINs as a capping/stabilizing agent. The MC-ZVINs and defroxamine were injected 5 times a week over 4 weeks. The total iron and Fe ~(3+) content of serum was determined by microwave plasma-atomic emission spectroscopy and an Fe ~(3+) ion measuring kit respectively and liver enzyme levels were evaluated with an auto-analyzer. Morphological changes of the liver were examined by haematoxylin and eosin and Prussian blue staining. Additionally, the bioactivity of the iron nanoparticles was checked by DPPH and nitric oxide radical scavenging activity, reducing power and iron (Fe ~(2+) ) chelating ability. Iron-overloaded mice treated with the MC-ZVINs, indicated a drastic reduction in serum iron content when compared with the control groups and those treated with defroxamine. MC-ZVINs exhibit satisfactory potency to chelate excessive iron in mice. The data collected in this study will be helpful for selecting the most appropriate operational conditions for synthesizing green ZVINs in biomedical applications.
机译：桃金娘-零价铁纳米粒子（MC-ZVINs）的绿色合成是在碱性环境中进行的。引入这些纳米颗粒用于在小鼠的铁超负荷地中海贫血模型中测试体内铁螯合。 MC-ZVIN的特点是使用成像（电子显微镜）和光谱法（紫外可见和红外吸收，动态光散射和X射线衍射）方法。这些方法表明，某些多酚作为封端剂/稳定剂结合到MC-ZVINs的表面。在4周内每周注射5次MC-ZVIN和右旋胺。分别通过微波等离子体原子发射光谱法和Fe〜（3+）离子测定试剂盒测定血清中的总铁和Fe〜（3+）含量，并使用自动分析仪评估肝酶水平。用苏木精和曙红和普鲁士蓝染色检查肝脏的形态变化。另外，通过DPPH和一氧化氮自由基清除活性，还原能力和铁（Fe〜（2+））螯合能力检查了铁纳米颗粒的生物活性。与对照组和用右旋糖胺治疗的小鼠相比，用MC-ZVINs处理的铁超负荷小鼠的血清铁含量大大降低。 MC-ZVINs具有令人满意的螯合小鼠体内过量铁的能力。这项研究中收集的数据将有助于选择最合适的操作条件，以在生物医学应用中合成绿色ZVIN。

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